Figure 2.
De novo activation of Bmp10 in mouse adult heart. A, a schematic diagram of the inducible Bmp10 transgenic mouse model and the de novo activation of Bmp10 in mouse adult hearts using an inducible Cre-LoxP transgenic strategy. B, hematoxylin and eosin staining of αMHC–eGFPf–Bmp10 and NTG control hearts to show normal cardiac histology in transgenic mice. C, validation of the successful activation of Bmp10 expression in adult ventricle by tamoxifen. D, normal cardiac hypertrophic response in tamoxifen-induced αMHC–eGFPf–Bmp10 mice in response to ISO treatment. NS, not significant.