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. 2019 Nov 11;294(52):19877–19888. doi: 10.1074/jbc.RA119.010943

Figure 3.

Figure 3.

De novo activation of Bmp10 preserves cardiac function. A, Sirus red/fast green staining showing a significantly reduced level of collagen deposition (red staining signal) in tamoxifen-induced transgenic heart in response to ISO treatment. B, significantly reduced number of activated caspase 3–positive cardiomyocytes in tamoxifen-induced transgenic hearts with ISO treatment. C, significantly reduced level of cleaved PARP in tamoxifen-induced transgenic hearts with ISO treatment. The quantification of the Western blotting is in Fig. S2. D, well-preserved cardiac systolic function in tamoxifen-induced transgenic mice with ISO treatment. E, i.p. injection of rhBMP10 into WT mice (DBA/2J) reduced cardiac fibrosis in response to ISO treatment compared with saline-injected control mice in response to ISO treatment. F, i.p. injection of rhBMP10 into WT mice (DBA/2J) significantly preserved cardiac systolic function in response to ISO treatment. EF%, ejection fraction; FS%, fractional shortening.