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. 2019 Nov 11;294(52):19877–19888. doi: 10.1074/jbc.RA119.010943

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© 2019 Qu et al.

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Figure 6. — The loss of BMP10-mediated cardiac protection in STAT3 cardiomyocyte-restrictive knockout mice (STAT3cko). A, echocardiographic measurement to show a similarly reduced level of fraction shortening and ejection fraction in ISO-treated STAT3cKO mice with or without rhBMP10 treatment. B, comparable number of activated caspase 3–positive cardiomyocytes in ISO-treated STAT3cKO heart with or without rhBMP10 treatment. C, representative images of Sirus red/fast green staining (left panel). The level of cardiac fibrosis was significantly reduced in ISO-treated STAT3cKO mice with rhBMP10 treatment compared with ISO-treated STAT3cKO mice without rhBMP10 treatment. EF%, ejection fraction; FS%, fractional shortening.