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Schematic diagram of BMP10-mediated dual activation of Smad and STAT3 pathways. BMP10 is able to activate Smad-mediated canonical pathway and potentially STAT3-mediated noncanonical pathway, both of which likely contribute to preserving the normal cardiac function via the inhibition of cardiomyocyte death and cardiac fibrosis. Future work will determine the underlying mechanism for BMP10-mediated STAT3 activation.
