Figure 7.

Structure-activity relationship analysis for ponalrestat. A, chemical structures of ponalrestat and its derivatives. B, estimation of chemical activities with root length index. Col-0 seeds were germinated and grown on 1/2 MS supplemented with or without 10 μm ponalrestat derivatives. The root lengths of 3-day-old seedlings were measured. The root length index is defined as the average root length of derivative-treated seedlings divided by the average root length of mock-treated seedlings. Bars represent mean ± S.D. of at least 10 seedlings. C, log P data for ponalrestat and derivatives calculated with ChemDraw.