Table 2.

Papers examining the outcomes of breast conserving surgery in multifocal multicentric breast cancer.

Study	Breast conserving surgery	Mastectomy	Conclusion
Nos et al (1999)23	56	132	No significant difference in the recurrence or survival rates
Kaplan et al (2003)24	36	19	Type of surgery had no impact on 5-year overall or disease-free survival
Oh et al (2006)26	20	27	No significant difference in disease-free or overall survival
Gentilini et al (2009)25	476	–	Local recurrence rate of 5.1% at 5 years
Lynch et al (2013)27	1757 UFBC	1059 UFBF	Breast conserving surgery is a safe option for MFBC
	256 MFBC	417 MFBC	All MCBC had mastectomy in this cohort
Wolters et al (2013)14	623 MFBC	319 MFBC	No significant difference in disease-free or overall survival
	60 MCBC	40 MCBC
Winters et al (2018)28	3537 MFMCBC	–	Breast conserving surgery and mastectomy had similar locoregional recurrence for MFMCBC. The conclusion was to support a future randomised trial

MCBC, multicentric breast cancer; MFBC, multifocal breast cancer; MFMCBC, multifocal multicentric breast cancer; UFBC, unifocal breast cancer.