Table 2.
Results of muscle function and muscle metabolism assessment
| Patients with CF (n = 20) | Healthy controls (n = 23) | |
|---|---|---|
| Wingate anaerobic test | ||
| Peak power (Watt) | 537 ± 180 (258–860) | 727 ± 186 (349–1145) *** |
| Mean power (Watt) | 378 ± 127 (202–619) | 486 ± 126 (226–747) *** |
| Power drop (Watt) | 12 ± 5 (5–25) | 8 ± 4 (2–15) *** |
| MRI spectroscopy – incremental knee-extension protocol | ||
| Maximal load (kg) | 6.8 ± 2.0 (3–11) | 8.1 ± 2.0 (5–13) * |
| Cross-sectional area M. quadriceps (cm3) | 57.7 ± 12.4 (38–79) | 62.8 ± 12.7 (27–86) |
| pH rest | 7.1 ± 0.02 (7.04–7.31) | 7.1 ± 0.02 (7.04–7.31) |
| pH maximum load | 7.08 ± 0.06 (6.99–7.21) | 7.08 ± 0.03 (7.02–7.19) |
| pH recovery | 7.03 ± 0.04 (6.92–7.07) | 7.04 ± 0.03 (6.97–7.11) |
| Pi/PCr rest | 0.15 ± 0.03 (0.11–0.23) | 0.15 ± 0.03 (0.11–0.21) |
| Pi/PCr maximum load | 0.34 ± 0.09 (0.21–0.59) | 0.36 ± 0.10 (0.23–0.63) |
| Pi/PCr recovery | 0.14 ± 0.03 (0.09–0.18) | 0.13 ± 0.02 (0.10–0.17) |
| Time to exhaustion (min) | 41.2 ± 7.8 (27–64) | 47.8 ± 8.4 (34–52) |
| Mean increment (kg) | 0.8 ± 0.3 (0.5–1) | 0.8 ± 0.2 (0.5–1) |
All parameters are reported as mean ± standard deviation (range); differences between participants with and without CF were calculated using Student’s t-test. Significant data is marked by ***p < 0.001, * p < 0.05