Table 4.
Participants’ characteristics/results of lung function, exercise testing, muscle function and muscle metabolism assessment in a subgroup performing a high-intensity, high-frequency constant load test to fatigue
| Subgroup | Patients with CF n = 5 | Healthy controls n = 10 |
|---|---|---|
| Female (n/[%]) | 1 [20%] | 6 [60%] |
| Anthropometric data | ||
| Age (years) | 23.6 ± 10.1 (13–40) | 25.5 ± 4.0 (23–35) |
| Height (cm) | 170.0 ± 14.1 (153–185) | 173.5 ± 8.6 (160–187) |
| Weight (kg) | 56.5 ± 15.4 (36.0–78.8) | 67.8 ± 12.1 (52.0–94.0) |
| Cross-sectional area M. quadriceps (cm3) | 59.4 ± 7.5 (48–69) | 58.1 ± 10.1 (46–71) |
| Lung function | ||
| FEV1%pred | 74.0 ± 13.2 (58.8–90.1) | 101.4 ± 17.3 (77.2–123.6) ** |
| FVC%pred | 86.9 ± 11.0 (75.4–101) | 98.3 ± 14.0 (77.2–111-9) |
| Incremental exercise test (Godfrey) | ||
| VO2 peak (%pred) | 77.2 ± 9.5 (87.4–102.1) | 117.7 ± 11.1 (106.0–136-0) *** |
| Wingate anaerobic test | ||
| Peak power (Watt) | 560 ± 182 (379–8599 | 714 ± 215 (480–1145) |
| Mean power (Watt) | 408 ± 136 (266–589) | 465 ± 153 (295–748) |
| Power drop (Watt) | 12.2 ± 4.4 (5.3–14.4) | 8.4 ± 3.5 (7.6–20.6) |
| MRI spectroscopy - high-intensity knee-extension protocol | ||
| Maximal load (kg) | 7.9 ± 2.0 (4.5–11) | 9.1 ± 2.5 (5–11) |
| Exercise time (sec) | 135 ± 78 (99–156) | 150 ± 51 (98–172) |
| Pi/PCr rest | 0.16 ± 0.04 (0.09–0.16) | 0.14 ± 0.03 (0.10–0.16) |
| Pi/PCr maximum | 0.85 ± 0.45 (0.58–1.64) | 0.96 ± 0.36 (0.42–1.44) |
| Pi/PCr recovery | 0.15 ± 0.09 (0.09–0.13) | 0.12 ± 0.06 (0.03–0.22) |
| pH rest | 7.02 ± 0.02 (7.00–7.05) | 7.03 ± 0.03 (6.99–7.02) |
| pH maximum | 7.01 ± 0.05 (6.98–7.11) | 7.01 ± 0.15 (6.81–7.25) |
| pH recovery | 6.91 ± 0.17 (6.61–7.06) | 6.96 ± 0.10 (6.82–7.11) |
All parameters are reported as mean ± standard deviation; differences between participants with and without CF were calculated using Student’s t-test. Significant data is marked by ***p < 0.001, ** p < 0.01