Table 2.
Spearman correlation coefficients (rS) between total cell number, percentage of neutrophils, total protein and inflammatory markers in induced sputum (values 24 h after all ZnO exposures were considered) with 95% confidence intervals and p-values
| Total cell number | Neutrophils [%] | Total Protein [μg/mL] | IL-8 [pg/mL] | MMP-9 [ng/mL] | TIMP-1 [ng/mL] | 8-iso-PGF2α [pg/mL] | Substance P [pg/mL] | IL-6 [pg/mL] | |
|---|---|---|---|---|---|---|---|---|---|
|
Total cell number [× 105] |
1 |
0.51* 0.35–0.67 < 0.0001 |
0.52* 0.37–0.67 < 0.0001 |
0.44* 0.28–0.61 < 0.0001 |
0.60* 0.46–0.73 < 0.0001 |
0.58* 0.45–0.71 < 0.0001 |
−0.07 -0.26-0.13 0.4931 |
−0.21* -0.40- -0.02 0.0315 |
0.35* 0.18–0.52 0.0002 |
|
Neutrophils [%] |
1 |
0.70* 0.60–0.78 < 0.0001 |
0.69* 0.58–0.82 < 0.0001 |
0.81* 0.73–0.89 < 0.0001 |
0.79* 0.70–0.87 < 0.0001 |
0.17 -0.02-0.36 0.3120 |
−0.26* -0.46- -0.07 0.0008 |
0.61* 0.48–0.75 < 0.0001 |
|
|
Total protein [μg/mL] |
1 |
0.85* 0.78–0.92 < 0.0001 |
0.84* 0.73–0.89 < 0.0001 |
0.88* 0.82–0.96 < 0.0001 |
0.34* 0.19–0.50 0.0003 |
−0.23* -0.42- -0.04 0.0193 |
0.56* 0.43–0.70 < 0.0001 |
||
|
IL-8 [pg/mL] |
1 |
0.87* 0.82–0.95 < 0.0001 |
0.90* 0.85–0.96 < 0.0001 |
0.37* 0.22–0.52 0.0001 |
−0.29* -0.48- - 0.10 0.0046 |
0.59* 0.47–0.71 < 0.0001 |
|||
|
MMP-9 [ng/mL] |
1 |
0.95* 0.94–0.97 < 0.0001 |
0.24* 0.08–0.40 0.0146 |
−0.28* − 0.46- -0.09 0.0046 |
0.68* 0.58–0.77 < 0.0001 |
||||
|
TIMP-1 [ng/mL] |
1 |
0.19* 0.02–0.35 0.0497 |
−0.33* -0.41- -0.15 0.0008 |
0.65* 0.54–0.77 < 0.0001 |
|||||
|
8-iso-PGF2α [pg/mL] |
1 |
0.17 -0.03-0.38 0.0791 |
0.05 -0.14-0.23 0.6389 |
||||||
|
Substance P [pg/mL] |
1 |
−0.24* -0.44- -0.03 0.0146 |
|||||||
|
IL-6 [pg/mL] |
1 |
Correlations with p < 0.05 are marked with asterisks