Table 1.

A schematic of the study timeline including the standard protocol items as defined by the 2013 SPIRIT statement [23, 24]

		Screening	Study period						Follow-up period
		T0	Day 1	Day 2	Day 3	Day 4	Day 5	Discharge	Day 7	Day 14	Day 28
Enrollment	Eligibility screen	x
	Informed consent	x
	Randomization and allocation		x
Intervention	Standardized workup		x	x	x
	Standardized therapy		x	x	x	x	x		x	x	x
	Drug or placebo (q8h)		x, x, x
Assessment	Complete blood count		x	x	x	x	x
	Serum chemistry (LDH, HI, Hb, bilirubin)		x	x	x	x	x
	C5b-9 complex		x	x	x	x	x
	Residual plasma complement		x	x	x	x	x
	Serum haptoglobin concentration		x	x	x	x	x
	Erythrocyte bound C3b		x	x	x	x	x
	Duration of hospitalization							x
	Red cell transfusion requirements							x
	Rescue therapy requirements							x
	Survival (Alive, died, euthanized)							x	x	x	x
Follow-up	Telephone follow-up								x	x	x