Table 1.
List of metabolic peptides significantly upregulated following CoQ10 supplementation as measured by TMT proteomic analysis
| Peptide | Accession Number | Permutation Test (p-value) Benjamini-Hochberg (p < 0.00834) |
Log Fold Change (HM + CoQ10 / HM + Placebo) |
|---|---|---|---|
| ATP binding cassette subfamily B member 8 | I3LMV8_PIG | 0.0037 | 0.2 |
| ATP synthase subunit alpha | A0A287AGU2_PIG (+ 1) | 0.001 | 0.1 |
| Citrate synthase | CISY_PIG | 0.003 | 0.2 |
| Coenzyme Q10A | F1SLZ5_PIG | 0.1 | 0.2 |
| Coenzyme Q10B | F1SMZ8_PIG | 0.034 | 0.34 |
| Coenzyme Q8A | A0A286ZK64_PIG | 0.001 | 0.28 |
| Coenzyme Q9 | I3LHS7_PIG | 0.005 | 0.26 |
| Glutamate dehydrogenase 1 | F1SEN2_PIG | 0.003 | 0.19 |
| Malate dehydrogenase | I3LP41_PIG (+ 1) | < 0.0001 | 0.22 |
| Methylcrotonoyl-CoA carboxylase 2 | A0A287B773_PIG | 0.003 | 0.23 |
| Mitochondrial import inner membrane translocase subunit TIM44 | A0A287ADX5_PIG | 0.00095 | 0.2 |
| NAD-dependent protein deacylase sirtuin-5 | A0A287AF07_PIG | 0.001 | 0.3 |
| NADH:ubiquinone oxidoreductase subunit V3 | I3LRR4_PIG [2] | < 0.0001 | 0.35 |
| NADH-cytochrome b5 reductase | F1S4N2_PIG | 0.001 | 0.23 |
| Oxoglutarate dehydrogenase | F1SSH8_PIG [3] | 0.003 | 0.15 |
| Propionyl-CoA carboxylase alpha | A0A287ALU0_PIG (+ 2) | 0.006 | 0.14 |
| Pyruvate dehydrogenase E1 component subunit alpha | I3LCI2_PIG | 0.00019 | 0.21 |
| Succinate--CoA ligase [ADP-forming] subunit beta | A0A287AR48_PIG (+ 1) | 0.001 | 0.26 |
| Succinate--CoA ligase [GDP-forming] subunit beta | A0A286ZWJ9_PIG | 0.00026 | 0.2 |
| Succinyl-CoA:3-ketoacid coenzyme A transferase 1 | SCOT1_PIG | 0.003 | 0.13 |
| Superoxide dismutase | A0A287A4Z2_PIG (+ 1) | 0.001 | 0.2 |