Table 1.
Collected information on central (mental) health outcomes in MOTAR
| Instrument | Method | Week 0 | Week 6 | Week 10 | Week 16 | Week 52 | |
|---|---|---|---|---|---|---|---|
| Primary outcomes | |||||||
| Biological aging: telomere length, telomerase activity | Fasting blood samples | Blood | X | – | – | X | X |
| Secondary outcomes | |||||||
| Biological and general health indicators | |||||||
| Biomarkers (inflammation, metabolic syndrome) | Fasting blood samples | Blood | X | – | – | X | X |
| Gene-expression (RNA) | Fasting blood samples | Blood | X | – | – | X | X |
| HPA-axis (cortisol) | 2 days of 6 saliva samples | Saliva | X | – | – | X | X |
| Oxidative stress | Urine sample | Urine | X | – | – | X | X |
| Autonomic nervous system | Electro + impedance cardiography, heart rate variability [81] | ME | X | – | – | X | X |
| Blood pressure | Systolic and diastolic BP | ME | X | – | – | X | X |
| Body composition | Weight, height, waist+ hip circumfereence | ME | X | – | – | X | X |
| Physical condition | Astrand sub max test [82] | ME | X | – | X | X | |
| Muscle strength | Hand grip strength [81] | ME | X | – | – | X | X |
| Lung function | Peak expiratory flow [82] | ME | X | – | – | X | X |
| Pain | Chronic graded pain scale [83] | Int | X | – | – | X | X |
| Somatization | Short somatization questionnaire [84] | SR | X | – | – | X | X |
| Disability severity | WHO-DAS II [85] | SR | X | – | – | X | X |
| Depressive and anxiety disorders | |||||||
| Presence of MDD | CIDI: MDD [78] | Int | X | – | – | X | X |
| Presence of anxiety dis | CIDI: SocPhob, Agora, GAD, PA [78] | Int | X | – | – | X | X |
| Course of symptoms | Life-chart [86] | Int | X | – | – | X | X |
| Severity of depression | Inventory of depressive symptoms [87] | SR | X | X | X | X | X |
| Severity of anxiety | Beck anxiety index [88] and Fear questionnaire [89] | SR | X | X | X | X | X |
| Sleep | Insomnia Rating Scale [90] | Int | X | – | – | X | X |
| Descriptive variables, potential confounding covariates and potential mediating variables | |||||||
| Age, gender, ethnicity | Standard questions | Int | X | – | – | – | – |
| Socio-economic status | Education, income, occupation | Int | X | – | – | – | – |
| Physical activity | SQUASH questionnaire [91] | SR | X | – | – | X | X |
| Smoking | Past + current smoking questions | SR | X | – | – | – | X |
| Medication use | Drug container observation | Int | X | – | – | X | X |
| Regular alcohol intake | AUDIT questionnaire [92] | SR | X | – | – | – | X |
| Somatic diseases | Presence + symptoms of disease | Int | X | – | – | X | X |
| Health care | Perceived need of care [93] | Int | X | – | – | X | X |
| Work and disability | Tic-P questionnaire [94] | Int | X | – | – | X | X |
| Personality | NEO-FFI questionnaire [95] | SR | X | – | – | X | X |
| Locus of control | Pearlin & Schooler mastery scale [96] | SR | X | – | – | X | X |
| Depression vulnerability | LEIDS-R questionnaire [97] | SR | X | – | – | X | X |
| Anxiety vulnerability | Anxiety senstivity index [98] | SR | X | – | – | X | X |
| Experimental cognitive task | Implicit association test (IAT) [99] | CT | X | – | X | X | |
| Experimental memory task | Digit Span (WAIS) [100] | Int | X | – | – | X | X |
| Important neg + pos life events | Brugha questionnaire [101] | Int | X | – | – | X | X |
| Childhood Trauma | Youth Trauma questionnaire [102] | SR | X | – | – | – | – |
| Familiy history | Familiy history inventory | Int | X | – | – | – | – |
| Neuroimaging assessment (subsample) | |||||||
| Verbal episodic memory | 15-words test [103] | MRI | x | – | – | x | x |
| Task-related brain activity | Emotional face matching paradigm and N-back paradigm [104] | MRI | x | – | – | x | x |
| Brain network connectivity | Resting state MRI images | MRI | x | – | – | x | x |
| Process indicators (intervention adherence) | |||||||
| Exercise intervention group: Exercise participation and heart rate will be administrated during each session.. | |||||||
| Antidepressant intervention group | Side effect medication questionnaire | Int | – | X | X | X | – |
| Adherence (pill count) | Int | – | X | X | X | – | |
SR self-report, Int interview, Blood data collection via fasting blood sample, CT computer task, ME medical examination