Table 1.
Relative abundance (%, median values) of family-specific 16S rRNA gene amplicon sequences in human faecal samples collected from healthy subjects and patients with primary progressive multiple sclerosis (PPMS)
| Family | PPMS | Healthy | p-value |
|---|---|---|---|
| Ruminococcaceae | 31.9 | 28.2 | 0.23 |
| Lachnospiraceae | 17.1 | 26.5 | 0.06 |
| Bacteroidaceae | 2.7 | 1.6 | 0.84 |
| Prevotellaceae | 1.8 | 1.0 | 0.74 |
| Bifidobacteriaceae | 4.0 | 2.1 | 0.44 |
| unc. Clostridiales a | 4.2 | 2.6 | 0.09 |
| Coriobacteriaceae | 2.2 | 1.4 | 0.15 |
| unc. Firmicutes | 2.3 | 0.3 | 0.01b |
| Veillonellaceae | 2.2 | 1.9 | 0.87 |
| Acidaminococcaceae | 1.1 | 0.02 | 0.04 |
| Porphyromonadaceae | 0.9 | 0.5 | 0.23 |
| unc. Clostridia | 0.5 | 0.07 | 0.04 |
| Eubacteriaceae | 1.5 | 0.5 | 0.01 |
| Rikenellaceae | 0.6 | 0.2 | 0.07 |
| Streptococcaceae | 0.3 | 0.6 | 0.59 |
| Erysipelotrichaceae | 0.4 | 0.4 | 0.62 |
| Verrucomicrobiaceae | 0.09 | 0.00 | 0.01 |
| unc. Bacteria | 0.31 | 0.06 | 0.16 |
| Peptostreptococcaceae | 0.5 | 0.1 | 0.12 |
| Lactobacillaceae | 0.01 | 0.00 | 0.10 |
| Methanobacteriaceae | 0.07 | 0.00 | 0.06 |
| Clostridiaceae_1 | 0.01 | 0.1 | 0.57 |
| Sutterellaceae | 0.09 | 0.06 | 0.93 |
| Desulfovibrionaceae | 0.36 | 0.05 | 0.00 |
| Enterobacteriaceae | 0.1 | 0.3 | 0.13 |
| Actinomycetaceae | 0.03 | 0.01 | 0.01 |
| Clostridiales_i.s._XIII | 0.003 | 0.000 | 0.17 |
| Oxalobacteraceae | 0.004 | 0.000 | 0.03 |
| Christensenellaceae | 0.005 | 0.000 | 0.01 |
| Corynebacteriaceae | 0.003 | 0.000 | 0.01 |
a “unc.” stands for unclassified;
b the rows with statistically significant (P ≤ 0.05) differences between the cohorts’ medians are highlighted in bold