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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Adv Drug Deliv Rev. 2019 Feb 12;148:344–359. doi: 10.1016/j.addr.2019.01.011

Fig. 2.

Fig. 2.

Zebrafish as a pre-clinical model to study the systemic circulation of nanocarrier drug delivery systems in vivo. Notably, changes in circulation patterns observed in zebrafish with various nanocarrier modifications paralleled pharmacokinetic distribution data collected from mammalian systems. Reproduced with permission of Journal of Controlled Release [60].