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. 2019 Dec 30;19:1264. doi: 10.1186/s12885-019-6453-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Knocking down TOPK attenuates the migration and invasion of esophageal squamous cell carcinoma (ESCC) cells. Knocking down TOPK expression in the KYSE510 (a) and KYSE30 cells (b) by lentiviral infection. Cell migration was evaluated at 0, 24, and 48 h in the stable TOPK knockdown cells (shTOPK-transfected KYSE510 (c) and KYSE30 cells (d)) by wound healing migration assay. The invasion of KYSE510 (e) and KYSE30 (f) cells was measured by transwell migration assay after knocking down TOPK. ***p < 0.001 vs shMock group