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. 2019 Dec 30;19:1264. doi: 10.1186/s12885-019-6453-z

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — The TOPK inhibitor, HI-TOPK-032 attenuates migration and invasion of esophageal squamous cell carcinoma (ESCC) cells. The KYSE510 cell (a) was treated with 0,0.5,1,5 and 10 μM HI-TOPK-032, while KYSE30 cell (b) was treated at 0, 0.25, 0.5,1 and 1.5 μM HI-TOPK-032 for 0, 24, 48 h and the cell migration was analyzed by wound healing assay. The KYSE510 (c) and KYSE30 cells (d) were treated with different concentrations of HI-TOPK-032 and seeded in the upper transwell chamber. The number of migrated cell was counted in transwell migration assay