Table 2.
Association of the investigated ESR1, ESR2, HER2, UGT1A4, and UGT2B7 SNPs and breast cancer (BC)
| Gene | SNP ID | Allelic and Genotypic Frequencies in Cases and Controls | ||||
|---|---|---|---|---|---|---|
| Allele/Genotype | Cases (n = 218) |
Controls (n = 219) |
P-value | Chi-square | ||
| ESR1 | rs2234693 | C | 222(0.51) | 221(0.51) | 0.943 | 0.005 |
| T | 216(0.49) | 213(0.49) | ||||
| CC | 60 (27.4) | 48 (22.1) | 0.069 | 5.328 | ||
| TC | 102 (46.6) | 125 (57.6) | ||||
| TT | 57 (26) | 44 (20.3) | ||||
| rs9340799 | A | 231(0.53) | 234(0.54) | 0.782 | 0.076 | |
| G | 205(0.47) | 200 (0.46) | ||||
| AA | 64 (29.4) | 54 (24.9) | 0.067 | 5.383 | ||
| AG | 103 (47.2) | 126 (58.1) | ||||
| GG | 51 (23.4) | 37 (17.1) | ||||
| rs3020410 | C | 399(0.9) | 399(0.92) | 0.387 | 0.748 | |
| A | 43(0.1) | 35(0.08) | ||||
| CC | 181 (81.9) | 184 (84.8) | 0.698 | 0.718 | ||
| CA | 37 (16.7) | 31 (14.3) | ||||
| AA | 3 (1.4) | 2 (0.9) | ||||
| rs3798577 | T | 258(0.59) | 224(0.52) | 0.024 | 5.033 | |
| C | 178(0.41) | 210(0.48) | ||||
| TT | 80 (36.7) | 56 (25.8) | 0.047 | 6.076 | ||
| TC | 98 (45) | 112 (51.6) | ||||
| CC | 40 (18.4) | 49 (22.6) | ||||
| ESR2 | rs1256049 | C | 434(0.98) | 425(0.98) | 0.777 | 0.08 |
| T | 8(0.02) | 9(0.02) | ||||
| CC | 213 (96.4) | 208 (95.8) | 0.774 | 0.082 | ||
| CT | 8 (3.6) | 9 (4.2) | ||||
| HER2 | rs1058808 | G | 300(0.68) | 296(0.68) | N/A | N/A |
| C | 140(0.32) | 138(0.32) | ||||
| GG | 101 (45.9) | 105 (48.4) | 0.503 | 1.372 | ||
| GC | 98 (44.5) | 86 (39.6) | ||||
| CC | 21 (9.6) | 26 (12) | ||||
| UGT1A4 | rs12468274 | T | 400(0.92) | 402(0.93) | 0.627 | 0.236 |
| C | 36 (0.08) | 32(0.07) | ||||
| TT | 182 (83.5) | 185 (85.2) | 0.611 | 0.258 | ||
| CT | 36 (16.5) | 32 (14.8) | ||||
| rs2011425 | T | 399(0.91) | 392(0.91) | 0.974 | 0.001 | |
| G | 39(0.09) | 38 (0.09) | ||||
| TT | 180 (82.2) | 177 (82.3) | 0.974 | 0.001 | ||
| TG | 39 (17.8) | 38 (17.7) | ||||
| rs6755571 | C | 416(0.94) | 413(0.95) | 0.694 | 0.154 | |
| A | 26(0.06) | 23(0.05) | ||||
| CC | 196 (88.7) | 197 (90.4) | 0.638 | 0.897 | ||
| CA | 24 (10.9) | 19 (8.7) | ||||
| AA | 1 (0.4) | 2 (0.9) | ||||
| UGT2B7 | rs28365062 | A | 371(0.84) | 362(0.83) | 0.605 | 0.267 |
| G | 69 (0.16) | 74(0.17) | ||||
| AA | 159 (72.3) | 152 (69.7) | 0.829 | 0.374 | ||
| GA | 53 (24.1) | 58 (26.6) | ||||
| GG | 8 (3.6) | 8 (3.7) | ||||
| rs4348159 | C | 369(0.84) | 361(0.83) | 0.785 | 0.074 | |
| T | 71(0.16) | 73(0.17) | ||||
| CC | 158 (71.8%) | 152 (70) | 0.860 | 0.3 | ||
| TC | 53 (24.1%) | 57 (26.3) | ||||
| TT | 9 (4.1%) | 8 (3.7) | ||||
P-Value < 0.05 was considered as significant