Table 3.
Genetic association analysis for the ESR1, HER2, UGT1A4, and UGT2B7 SNPs using different genetic models
| Gene | SNP ID | Category Test | Odds Ratio | 95% CI | Chi square* |
|---|---|---|---|---|---|
| ESR1 | rs2234693 | Het (GT) vs Common Hz (GG) | 0.65 | 0.41–1.04 | 3.31 |
| Rare Hz (TT) vs Het (GT) | 1.59 | 0.99–2.55 | 3.7 | ||
| Rare Hz (TT) vs Common Hz (GG) | 1.04 | 0.6–1.79 | 0.02 | ||
| rs9340799 | Het (AG) vs Common Hz (AA) | 0.69 | 0.44–1.08 | 2.67 | |
| Rare Hz (GG) vs Het (AG) | 1.69 | 1.03–2.77 | 4.29 | ||
| Rare Hz (GG) vs Common Hz (AA) | 1.16 | 0.67–2.03 | 0.28 | ||
| rs3020410 | Het (CT) vs Common Hz (CC) | 1.21 | 0.72–2.04 | 0.53 | |
| Rare Hz (TT) vs Het (AG) | 1.26 | 0.2–8.01 | 0.06 | ||
| Rare Hz (TT) vs Common Hz (CC) | 1.52 | 0.25–9.23 | 0.21 | ||
| rs3798577 | Het (GT) vs Common Hz (GG) | 0.61 | 0.4–0.95 | 4.88 | |
| Rare Hz (TT) vs Het (GT) | 0.93 | 0.57–1.53 | 0.07 | ||
| Rare Hz (TT) vs Common Hz (GG) | 0.57 | 0.33–0.98 | 4.16 | ||
| HER2 | rs1058808 | Het (GA) vs Common Hz (GG) | 1.18 | 0.8–1.76 | 0.7 |
| Rare Hz (AA) vs Het (GA) | 0.71 | 0.37–1.35 | 1.1 | ||
| Rare Hz (AA) vs Common Hz (GG) | 0.84 | 0.44–1.59 | 0.29 | ||
| UGT1A4 | rs6755571 | Het (GA) vs Common Hz (AA) | 1.27 | 0.67–2.39 | 0.55 |
| Rare Hz (GG) vs Het (GA) | 0.4 | 0.03–4.7 | 0.57 | ||
| Rare Hz (GG) vs Common Hz (AA) | 0.5 | 0.05–5.59 | 0.33 | ||
| UGT2B7 | rs28365062 | Het (CT) vs Common Hz (CC) | 0.87 | 0.57–1.35 | 0.37 |
| Rare Hz (TT) vs Het (CT) | 1.09 | 0.38–3.12 | 0.03 | ||
| Rare Hz (TT) vs Common Hz (CC) | 0.96 | 0.35–2.61 | 0.01 | ||
| rs4348159 | Het (CT) vs Common Hz (CC) | 0.89 | 0.58–1.38 | 0.25 | |
| Rare Hz (TT) vs Het (CT) | 1.21 | 0.43–3.37 | 0.13 | ||
| Rare Hz (TT) vs Common Hz (CC) | 1.08 | 0.41–2.88 | 0.03 |
* For significant association χ2 should be > 3.84 with P < 0.025
CI indicates confidence interval