Table 4.

Association between different ESR1 and ESR2 SNP genotypes and the Clinico-pathological attributes of breast cancer (BC)

Clinical attributes of BC	ESR1				ESR2
	rs3020410 CC vs CA vs AA	rs3798577 CC vs CT vs TT	rs2234693 CC vs CT vs TT	rs9340799 AA vs AG vs GG	rs1256049 CC vs CT
Age at BC diagnosis b	0.632	0.528	0.179	0.190	0.019
Age at first pregnancy b	0.904	0.295	0.128	0.318	0.634
Age at menarche b	0.741	0.866	0.154	0.138	0.570
Age at menopause b	0.965	0.077	0.627	0.664	0.533
Allergy a	0.300	0.893	0.886	0.749	0.625
Body mass index b	0.627	0.209	0.126	0.007	0.983
Breastfeeding status a	0.206	0.497	0.895	0.540	0.448
Co-morbidity a	0.914	0.719	0.485	0.615	0.868
Family history a	0.450	0.032	0.674	0.706	0.497
Smoking a	0.067	0.722	0.868	0.575	0.415
Pathological attributes of breast cancer (BC)
Axillary lymph nodes a	0.434	0.314	0.078	0.266	0.805
Estrogen receptor status a	0.012	0.398	0.803	0.517	0.569
HER2 a	0.561	0.642	0.152	0.420	0.492
Histology classification a	0.702	0.610	0.818	0.898	0.806
Lymph node involvement a	0.772	0.362	0.318	0.255	0.534
Progesterone receptor status a	0.966	0.756	0.536	0.495	0.736
Tumor differentiation a	0.970	0.399	0.596	0.849	0.056
Tumor size b	0.032	0.177	0.637	0.619	0.536
Tumor stage a	0.793	0.158	0.199	0.155	0.614

^aPearson’s chi-squared test was used to determine genotype-phenotype association

^bAnalysis of variance (ANOVA) was used to determine genotype-phenotype association