Table 6.
Haplotypic analysis of ESR1, ESR2, and UGT1A4 polymorphisms
| Haplotype | Frequency of block | Frequency ratio (case:control) (%) |
Odds ratio (95% CI) |
P-value |
|---|---|---|---|---|
| ESR1 and ESR2 Block (rs3020410, rs3798577, rs1256049, rs2234693, and rs9340799) | ||||
| CTCCG | 0.2417 | 0.2761: 0.232 | 1:00 | N.A |
| CTCTA | 0.2358 | 0.2172: 0.2345 | 0.90 (0.56–1.45) | 0.66 |
| CCCCG | 0.1957 | 0.2025: 0.1681 | 0.61 (0.35–1.04) | 0.071 |
| CCCTA | 0.1702 | 0.2008: 0.1538 | 0.65 (0.42–1.02) | 0.061 |
| ACCTA | 0.0355 | 0.0266: 0.0391 | 0.73 (0.27–1.94) | 0.53 |
| ATCTA | 0.0355 | 0.0414: 0.0382 | 1.16 (0.46–2.89) | 0.76 |
| CCCCA | 0.0277 | 0.0291: 0.0274 | 0.80 (0.31–2.04) | 0.64 |
| CTCCA | 0.0186 | 0.0168: 0.0194 | 0.81 (0.22–2.92) | 0.74 |
| Global haplotype association p-value: 0.47 | ||||
| UGT1A4 Block (rs12468274, rs2011425, and rs6755571) | ||||
| TTC | 0.8552 | 0.8557:0.8548 | 1.00 | N.A |
| CGC | 0.0771 | 0.0726: 0.0816 | 1.12 (0.65–1.92) | 0.69 |
| TTA | 0.0526 | 0.0501:0.0551 | 1.07 (0.59–1.95) | 0.82 |
| TGC | 0.0118 | 0.019: 0.0048 | 0.25 (0.05–1.21) | 0.086 |
| Global haplotype association p-value: 0.39 | ||||