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. 2019 Dec 30;9:104. doi: 10.1186/s13578-019-0359-y

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Prediction for circ_0001667/miRNA interactions and miRNA-mediated signaling pathways. a The interaction of circ_0001667-miR-125a-5p was predicted based on TargetScan and miRanda. b MiRNA expression in MDA-MB-468 cells. The miRNAs including miR-200c-3p, miR-203a-3p, miR-429, miR-5010-3p, miR-183-5p, miR-539-5p, miR-591, miR-125a-5p and miR-2113 were tested in MDA-MB-468 cells with circ_0001667 up-regulation by transfection. c Gene Ontology (GO) enrichment analysis of the target genes corresponding to circ_0001667. d Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the target genes showing the upregulated circ_0001667-related pathways. **p < 0.01