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. 2019 Dec 30;12:201. doi: 10.1186/s12920-019-0649-6

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — MEG3 is a ceRNA of miR-361-5p in OA chondrocytes a, the binding sites of MEG3 and miR-361-5p predicted by bioinformatics analysis. b, luciferase reporter gene assay showed that the microRNA-361-5p mimic reduced the luciferase activity of MEG3-Wt in chondrocytes. c, the concentration of MEG3 and miR-361-5p in IgG or Ago2 immunoprecipitates detected by RIP and qRT-PCR. d and e, the expression of miR-361-5p in OA tissues or cells was examined by qRT-PCR. f, Spearman analysis determined that miR-361-5p was negatively associated with MEG3; *, P < 0.05 compared with Blank group or pcDNA3.1-NC group. &, P < 0.05 compared with si-NC group. Data expressed as mean ± standard deviation (SD)