Table 3.

KEGG pathways associated with over-expressed (A) and under-expressed DEG (B) in the blood

Term	# of genes	pFDR
A. Under-expressed genes in LE compared to CT
Metabolic pathways	61	7.92 × 10−05
Biosynthesis of amino acids	10	2.18 × 10−03
Carbon metabolism	11	8.02 × 10−03
Fructose and mannose metabolism	6	9.32 × 10−03
Steroid biosynthesis	5	9.32 × 10− 03
Amino sugar and nucleotide sugar metabolism	7	9.32 × 10−03
Pentose phosphate pathway	5	2.20 × 10−02
Galactose metabolism	5	3.82 × 10−02
B. Over-expressed genes in LE compared to CT
Ribosome	13	2.95 × 10−02
RNA degradation	9	3.24 × 10− 02