Table 3.
Summary of all criteria as proposed by us for the definition of the oligometastatic disease in pancreatic cancer
| Criteria for Oligometastatic Disease in Pancreatic Ductal Adenocarcinoma | ||
|---|---|---|
| Inclusion | Exclusion | |
| ECOG | 0/1 | >/= 2 |
| Liver/lung only (+LN hepatoduodenal lig.) | Yes | No |
| Number of hepatic or pulmonary lesions | </= 4 | > 4 |
| Ascites | No | Yes |
| Liver cirrhosis | No | Yes |
| Lung emphysema | No | Yes |
| CA 19–9 (U/mL)a | < 1000 | > 1000 |
| Surgery for metastasisb | Atypical resection (+/−Ablation) | Non-resectable/major hepatic/lung surgery necessary |
| Primary tumor upon diagnosisb | Resectable, borderline resectable, non-resectablec | |
| Chemotherapy response | Response or stable disease | Progressive disease |
aHartwig et al. 2013 Ann Surg Oncol (2013) 20:2188–2196; DOI 10.1245/s10434-012-2809-1: R0 Resection rate CA 19-9 > 1000U/ml as low as 15%
bResectability of primary tumor and expected extension of hepatic resection to be evaluated by experienced HPB surgeon together with a radiologist
cAs defined in: Isaji, S. et al. International consensus on definition and criteria of borderline resectable pancreatic ductal adenocarcinoma 2017. Pancreatology 18, (2018)