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. 2019 Dec 30;19:231. doi: 10.1186/s12876-019-1147-1

Table 1.

Quality assement of eligible literatures

Quality Assesment
RCT study Author Prospective design Clear definition of study population (1) (2) (3) (4) (5)
Abraldes, et al. 2009 [21] Yes Yes Yes Stable Yes Yes Yes
Pollo-Flores, et al. 2015 [32] Yes Yes Yes Stable Yes Yes Yes
Abraldes, et al. 2016 [22] Yes Yes Yes Stable Yes Yes Yes
Bishnu, et al. 2018 [24] Yes Yes Yes Stable Yes Yes Yes
Elwan, et al. 2018 [26] Yes Yes Yes Stable Yes Yes Yes
Domenico, et al Yes Yes Yes Stable Yes Yes Yes
non-RCT study Author Study design Clear definition of study population Clear definition of different type of statin Clear definition of related endpoints Blindness to a statin or placebo

Representativeness

of the study population

Comparability between case and control groups
Kumar, et al. 2014 [30] Propensity Score Matching Case-control Study Yes Yes Yes No Yes Yes
Simon, et al. 2015 [34] Cohort study Yes No Yes Not given Yes Yes
Yang, et al. 2015 [37] Propensity Score Matching Case-control Study Yes No Yes No Yes Yes
Huang, et al. 2017 [27] Propensity Score Matching Case-control Study Yes No Yes No Yes Yes
Mohanty, et al. 2016 [31] Propensity Score Matching Case-control Study Yes Yes Yes Not given Yes Yes
Simon, et al. 2016 [33] Case-control Study Yes Yes Yes No Yes Yes
Bang, et al. 2017 [23] Case-control Study Yes No Yes No Yes Yes
Chang, et al. 2017 [25] Propensity Score Matching Case-control Study Yes No Yes Not given Yes Yes
Kim, et al. 2017 [13] Nested Case-control Study Yes Yes Yes No Yes Yes
Wong, et al. 2017 [36] Propensity Score Matching Case-control Study Yes Yes Yes No Yes Yes
Wani, et al. 2017 [35] Self-control Study (Prospective Cohort) Yes Yes Yes No Yes Yes
Kaplan, et al. 2019 [28] Propensity Score Matching Case-control Study Yes No Yes Not given Yes Yes

(1) whether the study design was suitable for the disease condition and statin treatment; (2) were statin treatment stable or fluctuating; (3) was different cohort comparable to each other; (4) was there any clear definition of end event; (5) was plan of follow-up clearly given