Figure 4.

Epidermal growth factor receptor (EGFR) mediates enhanced pressure- and ET-1–dependent vasoconstrictor reactivity after CH. (A–C) Basal arterial tone in nonpermeabilized arteries (A and B) and vasoconstrictor responses to ET-1 in Ca²⁺-permeabilized arteries (C) in the presence of the EGFR inhibitors AG1478 (1 μM; A and C), gefitinib (50 μM; B), or their respective vehicles. All arteries were endothelium disrupted. Values are means ± SE of n = 4–6 rats/group. *P < 0.05 versus control. ^#P < 0.05 CH drug versus CH vehicle.