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EGFR contributes to CH-induced right ventricular hypertrophy and increases in right ventricular systolic pressure (RVSP). Right ventricle/left ventricle plus septum weight (RV/LV+S; A) and peak RVSP (B) from CH and control rats treated chronically with the EGFR inhibitor gefitinib (30 mg/kg/d) or vehicle pills. Heart rates were not significantly different between groups (Table 2). Values are mean ± SE of n = 4–5 rats/group. *P < 0.05 versus control. #P < 0.05 versus CH vehicle.
