Table 6.
Ex vivo Permeation Parameters of SUT-Loaded Transferosomes versus SUT Solution
| Formula | Q6h (µg/cm2) | J (µg/cm2 h) | Kp (cm/h) | Lag Time (min) |
|---|---|---|---|---|
| Control I (SUT sol.) | 153.31 | 25.55 | 2.296787±0.34403 | 44.03 |
| Control II (SUT transferosomes) | 254.63 | 42.43 | 0.872257±0.11038 | 23.01 |
| G5/F9 | 616.12 | 102.69 | 18.8331±1.131814 | 8.11 |
| G5/F10 | 437.09 | 72.85 | 11.13888±0. 981124 | 21.46 |
| G5/F11 | 508.78 | 84.80 | 11.32028±1.079142 | 10.68 |
| G5/F12 | 380.64 | 63.44 | 5.94090±0.845185 | 23.39 |
Notes: G5; gel (PLX 407 (20%), PLX 188 (%w/v), carrageenan (%w/v)). Q6h (µg/cm2); amount of SUT permeated (µg) per area of the membrane, J is permeation flux.
Abbreviations: F, transferosomal formulations; Kp, the permeation coefficient.