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. 2018 Sep 20;68(11):1823–1830. doi: 10.1093/cid/ciy801

Figure 3.

Figure 3.

A, Estimated platform average weighted accuracy (AWA) for ceftolozane/tazobactam (TOL/TAZO) and ceftazidime/avibactam (CZA) as a function of the relative importance (r) of a false resistance determination relative to a false susceptibility determination over the relevant prevalence range for Pseudomonas aeruginosa resistance (5%–20%). The AWA for the Acuitas Resistome test and VERIGENE gram-negative blood culture test platforms are equivalent given the same resistance and susceptibility sensitivities. The AWA for the best random test (BRT) is also presented. B, Estimated difference and associated 95% confidence bands in platform AWA for TOL/TAZO and the BRT as a function of the relative importance (r) of a false resistance determination relative to a false susceptibility determination over the relevant prevalence range for P. aeruginosa resistance (5%–20%). The platforms are statistically superior to the BRT when the relative importance of a false resistance is more than 4% of a false susceptibility determination for TOL/TAZO. C, Estimated difference and associated 95% confidence bands in platform AWA for CZA and the BRT as a function of the relative importance (r) of a false resistance determination relative to a false susceptibility determination over the relevant prevalence range for P. aeruginosa resistance (5%–20%). The platforms are statistically superior to the BRT when the relative importance of a false resistance is more than 9% of a false susceptibility determination for CZA. Abbreviations: AWA, average weighted accuracy; BRT, best random test; CZA, ceftazidime/avibactam; RMD, rapid molecular diagnostic; TAZO, tazobactam; TOL, ceftolozane.