Table 1.
Variable | 503 | 1018 | 3017 | 340 | 3025 | 3026 | Escape (Median)a | Suppressed (Median, Interquartile Range) | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Gender | Female | Male | Male | Male | Male | Male | … | … | ||||
Race | Black or African American | Black or African American | Black or African American | American Indian/Alaska Native | White | White | … | … | ||||
T1 | T2 | T1 | T2 | T1 | T2 | T3 | … | … | ||||
Age (years) | 52 | 53 | 48 | 48 | 48 | 39 | 39 | 42 | 42 | 47 | 48 | 50 (42–56) |
CSF VL (copies/mL) | 117 | 89 | 47 | 209 | 54 | 1295 | <40 | 265 | 356 | <40 | 117 | <40b |
Plasma VL (copies/mL) | <40 | <40 | <40 | 62 | <40 | <40 | <40 | <40 | <40 | <40 | <40 | <40b |
CD4 (cells/mm3) | 430 | 567 | 325 | 327 | 210 | 261 | 200 | 309 | 503 | 326 | 539 (389–693)b | |
Nadir CD4 (cells/mm3) | 298 | 296 | 150 | 103 | 12 | 10 | 127 | 133 (34–253)c | ||||
CSF white blood cell count (cells/mm3) | 3 | 134 | 1 | 1 | 87 | 4 | 2 | 1 | 2 | 2 | 1 (1–3)b | |
Months on ART | 12 | 13 | 32 | 83 | 85 | 19 | 28 | 23 | 31 | 83 | 23 | 62 (19–123)d |
ART regimen | EFV, FTC, TDF | EFV, FTC, TDF | EFV, FTC, TDF | DRV/r, TDF, FTC | DRV/r, TDF, FTC | DRV/r, TDF, FTC | DRV/r, TDF, FTC | DRV/r, TDF, FTC | DRV/r, TDF, FTC | BIC, FTC, TAF | … | … |
ART regimen resistance mutations | N/A | N/A | N/A | N/A | N/A | None | N/A | M184V | M184V | N/A | … | … |
Abbreviations: ART, antiretroviral therapy; BIC, bictegravir; CSF, cerebrospinal fluid; DRV/r, ritonavir-boosted darunavir; EFV, efavirenz; FTC, emtricitabine; N/A, not measured; T1, time point 1; T2, time point 2; T3, time point 3; TDF, tenofovir disoproxil fumarate; VL, viral load.
aFor participants with multiple escape time points, an average value was generated and used to calculate the median.
bA total of 95 participants.
cA total of 94 participants.
dA total of 92 participants.