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. 2019 Dec 27;12:11507–11516. doi: 10.2147/OTT.S222564

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© 2019 Liu et al.

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The AKT inhibitor LY294002 rescued the function of ARHGAP10 in CRC cells. (A). The proliferation rate of siARHGAP10 transfected cells was reduced in the presence of the AKT inhibitor LY294002. *p < 0.05 vs siNC, ***p < 0.001 vs siNC; ^###p < 0.001 vs siARHGAP10. (B). The AKT inhibitor LY294002 inhibited the migration and invasion of siARHGAP10 transfected cells. ***p < 0.001 vs siNC; ^###p < 0.001 vs siARHGAP10. (C). The protein content of MMP2, MMP9, p-AKT and AKT were reduced by the AKT inhibitor LY294002. ***p < 0.001 vs siNC; ^###p < 0.001 vs siARHGAP10.