Table 2:

General doses of vitamins/co-factors in mitochondrial diseases.

SUBSTANCE	DOSE	REFERENCE
Arginine	Acute: 500 mg/kg IV per day (for 1–3 days) Maintenance dose: 150–300 mg/kg per day oral divided 2–3 times a day	[19, 32]
Alpha lipoic acid	50–200 mg/d	[32]
B50 or B100 (B vitamin complexes)	1 tablet oral given 1–2 times a day	[32]
Creatine	Paediatric: 0.1 g/kg per day oral. Adult: 10 g per day oral. Divided 1–2 times per day	[32]
CoQ10 (Ubiquinol)	Pediatric: 2–8 mg/kg per day oral divided in two doses Adult: 50–600 mg per day oral	[32]
Riboflavin (B2)	50–400 mg per day oral	[32]

IV: intra venous