Table.

Epidiolex (Cannabidiol): Frequently Asked Questions for Patients and Caregivers (cont.)

Question	Response
If my child is allergic to strawberries or sesame seeds, can they take Epidiolex?	Epidiolex can be given to patients with strawberry allergies because it only contains strawberry flavoring. However, as with any allergy, it is important to discuss with your child's physician first. Epidiolex is not recommended for patients who have a sesame seed allergy because Epidiolex is made in sesame oil.
How should Epidiolex be stored?	It should be stored at room temperature and can be used within 12 weeks of opening. It is important to throw away any remaining medication after 12 weeks.
Does Epidiolex interact with my child's other medications?	There is a possibility that Epidiolex may interact with other prescription, non-prescription, and herbal medications that your child may be taking. Please speak to your doctor or pharmacist before starting this medication. You should also make sure they are aware anytime you add a new prescription or non-prescription drug. If you have any questions regarding other medications, talk to your doctor or pharmacist.
How is Epidiolex given?	It is given twice daily and is dosed based on your child's weight. It is important that Epidiolex be given consistently with meals and given around the same time each day.
Can Epidiolex be given with food?	Although Epidiolex can be given with or without food, it is preferred that it be given with meals.
Can Epidiolex be administered through a gastrostomy (G-tube)?	Yes; however, the G-tube should be flushed well. Give Epidiolex first, followed with water, then give some formula, and follow with water to flush the G-tube well. Please discuss this with your physician. (Greenwich Biosciences Inc., written communication, June 12, 2019).
Is Epidiolex compatible with my child's ketogenic diet?	Yes. It may be given to your child if they are on the ketogenic diet. You should discuss with your doctor, dietitian, or pharmacist about your dietary therapies and any changes before starting Epidiolex.
What are the most common side effects of Epidiolex that my child may experience?	The most common reported side effects include drowsiness, diarrhea, decreased appetite, lack of energy, sleep problems, increased liver enzymes, and infections.
Can my child overdose on Epidiolex?	As with any medication, overdoses or taking more than prescribed by your child's doctor can be harmful. If you suspect an overdose, accidental or not, please call your physician or poison control at (800) 222–1222.
Where can I get Epidiolex?	Epidiolex is only dispensed through specialty pharmacies. Someone from the pharmacy will verify your child's prescription and work with your insurance company.
Will medical insurance cover Epidiolex?	Yes, most plans do. There is an approval process that can take days to a few weeks. It is approved for patients 2 years and older with a diagnosis of Lennox-Gastaut syndrome or Dravet syndrome.
Is there financial or patient support for Epidiolex?	The manufacturer has a support program. “Epidiolex Engage” includes an Epidiolex Copay Savings Program. Talk to your doctor or pharmacist should you have any concerns about affording your medications. https://www.epidiolex.com/engage-patient-support/assistance

CBD, cannabidiol; FDA, US Food and Drug Administration; THC, tetrahydrocannabinol