Table 2. Hazard ratios for death from breast cancer and all causes in women aged 70 years and over and women with high comorbidity.

Real world evidence method	N	Breast cancer death			Death from any cause
		Deaths	HR	95% CI	Deaths	HR	95% CI
Reference1			0.71	0.62–0.83		0.83	0.73–0.94
Women aged ≥70 years
PSM	1,298	431	0.78	0.64–0.95	568	0.71	0.60–0.85
IV1	9,653	1,935	0.57	0.42–0.74	3,953	0.61	0.49–0.74
IV2	9,653	1,935	0.57	0.42–0.73	3,953	0.63	0.50–0.76
Women with high comorbidity
PSM	2,034	254	0.67	0.51–0.86	421	0.67	0.56–0.82
IV1	7,965	740	0.68	0.42–1.10	1,388	0.92	0.63–1.33
IV2	7,965	740	0.59	0.37–0.99	1,388	0.82	0.58–1.22

¹Early Breast Cancer Trialists’ Collaborative Group meta-analysis of newer anthracycline-containing regimens versus placebo [2].

IV, instrumental variable; PSM, propensity score matching.