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. 2019 Dec 31;14(12):e0226771. doi: 10.1371/journal.pone.0226771

Fig 1. Overview of the Metabochip PheWAS study.

Fig 1

Three different PAGE study sites contributed data to the project: Atherosclerosis Risk in Communities (ARIC); the Women’s Health Initiative (WHI), and the Multiethnic Cohort (MEC). Comprehensive tests of association between 144,740 Metabochip SNPs and 273 phenotypes were calculated for African American participants from each of the three PAGE study sites. Similar phenotypes that were collected across the studies were binned into “phenotype classes”. Our PheWAS-significant criteria required an association at p<0.01 in at least two PAGE study sites for the same phenotype class and direction of effect.