Table 1. Population Architecture using Genomics and Epidemiology (PAGE) I studies available for PheWAS and their characteristics.

The Atherosclerosis Risk in Communities (ARIC), Multiethnic Cohort (MEC), and Women’s Health Initiative (WHI) from the PAGE I study contributed data towards this PheWAS. A full list of phenotypes used in this PheWAS is available in S1 Table. Some of the phenotypes were measured in more than one study, some phenotypes were related to phenotypes of another study, and some phenotypes were unique measurements for a single study. Not all phenotypic measurements were available for all participants within each study. Maximum sample size and minimum sample size are dependent both on which individuals were genotyped and which individuals also had a specific phenotype measured. See Materials and methods for more information.

Study	Age Range (in years)	Sex	Number of Phenotypes	Maximum Sample Size	Minimum Sample Size
ARIC	45–64	Males and Females	98	3,430	47
MEC	45–75	Males and Females	43	549	14
WHI	50–79	Females only	121	2,186	13