Table 2. Most significant and previously reported genotype-phenotype associations identified in the Population Architecture using Genomics and Epidemiology (PAGE) I study.
Presented are the two most significant individual-level results for this PheWAS, along with other highly significant results for the same phenotype with a different transformation and/or study where the phenotype was available. Abbreviations: allele frequency (AF), standard error (SE).
| SNP (Gene) |
Phenotype | Phenotype Transformation | Study | P-value | Beta (SE) |
Sample Size | Coded Allele | AF |
|---|---|---|---|---|---|---|---|---|
| rs6676438 (OLFML2B) |
White blood count | Natural log | ARIC | 8.01E-44 | 0.14 (0.01) |
3,212 | G | 0.12 |
| rs6676438 (OLFML2B) |
White blood count | None | ARIC | 4.17E-37 | 0.96 (0.08) |
3,212 | G | 0.12 |
| rs6676438 (OLFML2B) |
White blood count | Natural log | WHI | 8.99E-25 | 0.12 (0.01) |
2,087 | G | 0.16 |
| rs6676438 (OLFML2B) |
White blood count | None | WHI | 9.57E-06 | 3.38 (0.76) |
2,087 | G | 0.16 |
| rs7412 (APOE) |
Apolipoprotein B (mg/L) | Natural log | ARIC | 1.84E-40 |
-0.18 (0.01) |
3,061 | A | 0.11 |
| rs7412 (APOE) |
Apolipoprotein B (mg/L) | None | ARIC | 5.87E-32 | -148.6 (12.49) |
3,061 | A | 0.11 |