Table 4. Concomitant PheWAS results in African Americans from the Population Architecture using Genomics and Epidemiology (PAGE) study.
Test of association results (p-values, betas, standard errors) are shown for variants associated at p-value <0.01 (empirically defined) with two or more phenotype classes. An asterisk in the direction of effect column indicates an opposite direction of effect for two of the phenotype classes listed. Genomic position given is based on hg38. Allele frequency is based on all African Americans across PAGE studies regardless of phenotype.
| DE | rsID | Chromosome: position | Phenotype classes | PAGE Study | Phenotype | P-Value | Beta(se) | Sample size | CA | AF |
|---|---|---|---|---|---|---|---|---|---|---|
| rs10889334 | Chr1: 62491528 | Smoking, LDL-C | WHI, WHI, WHI, WHI, WHI, ARIC, MEC, WHI | Years a regular smoker, Normalized LDL, Natural Log normalized LDL, Smoking—current (Y/N), Pack years of smoking, LN+1 RE-CALIBRATED LDL CHOL. in mg/dl, LN+1 SMKQUIT, Number of years since quit smoking (reported at baseline), LN+1 years a regular smoker | 3.35e-3, 3.63e-3, 4.53e-3, 5.45e-3, 6.19e-3, 7.18e-3, 7.74e-3, 8.57e-3 | -1.96e-1 (0.07), -4.73e0 (1.62), -3.71e-2 (0.01), -2.92e-1 (0.11), -1.20e0 (0.44), -2.37e-2 (8.82e-3), 0.10 (0.04), -6.52e-2 (0.02) | 2029, 1120, 1120, 2186, 2017, 3162, 230, 2029 | C | 0.34 | |
| rs61771778 | Chr1: 72461172 | CRP, MI | MEC, MEC, MEC, WHI, WHI, WHI | C-Reactive Protein, LN+1 C-Reactive Protein, Heart attack reported at baseline (Y/N), Age at MI, LN+1 CRP, LN+1 F2 age at MI | 1.81e-4, 4.08e-4, 1.90e-3, 3.75e-3, 6.25e-3, 9.06e-3 | 2.13 (0.56), 0.42 (0.12), 1.23 (0.40), 2.37 (0.73), 0.26 (0.09), 0.56 (0.20) | 380, 380, 455, 27, 1071, 27 | G | 0.043 | |
| rs2994429 | Chr1: rs2994429 | Hemoglobin, Hematocrit | WHI, WHI, ARIC, WHI, WHI, ARIC | LN+1 Hemoglobin, Hemoglobin, LN+1 HEMATOCRIT, Hematocrit, LN+1 Hematocrit, LN+1 HEMOGLOBIN | 5.83e-5, 1.09e-4, 2.17e-4, 8.82e-4, 9.40e-4, 2.76e-3 | 0.01 (2.54e-3), 0.14 (0.04), 9.29e-3 (2.51e-3), 0.36 (0.11), 8.65e-3 (2.61e-3), 7.43e-3 (2.48e-3) | 2086, 2086, 3213, 2087, 2087, 3213 | A | 0.32 | |
| rs10798572 | Chr1: 177821975 | Hypertension, Smoking | MEC, ARIC, WHI, ARIC | High blood pressure reported at baseline, CIGARETTE YEARS OF SMOKING, Smoking—current (Y/N), Blood Pressure Lowering Medications in the past 2 weeks—Took medication | 1.62e-3, 6.90e-3, 8.74e-3, 9.27e-3 | -4.71e-1 (0.15), -3.08e1 (11.41), -3.17e-1 (0.12), -1.51e-1 (0.06) | 455, 3234, 2186, 3430 | G | 0.27 | |
| rs943763 | Chr1: 177867129 | LDL-C, Smoking | WHI, WHI, WHI, MEC, MEC, ARIC, ARIC, ARIC | LN+1 normalized LDL, normalized LDL, Smoking—Former (Y/N), Pack-years of smoking (cigarettes) reported at baseline, LN+1 Pack-years of smoking (cigarettes) reported at baseline, Cigarette smoking status—Former smoker, LN+1 RE-CALIBRATED LDL CHOL. in mg/dl, HAVE YOU EVER SMOKED CIGARETTES? (Y/N) | 6.59e-4, 9.64e-4, 2.12e-3, 3.46e-3, 5.13e-3, 6.29e-3, 7.99e-3, 8.13e-3 | 0.05 (0.01), 5.50 (1.66), 0.20 (0.06), 0.35 (0.12), 0.09 (0.03), -1.62e-1 (0.06), 0.02 (8.71e-3), -1.37e-1 (0.05) | 1120, 1120, 2186, 435, 435, 3426, 3159, 3333 | C | 0.46 | |
| rs1052238 | Chr1: 198665496 | CRP, Diabetes | WHI, ARIC, ARIC, ARIC, WHI | LN+1 CRP, C-reactive Protein, LN+1 C-reactive Protein, Diabetes—lower threshold 126 mg/dL—YES, Age first told had diabetes | 3.25e-4, 2.63e-3, 7.85e-3, 8.70e-3, 9.70e-3 | -0.13 (0.04), 3.12 (1.02), 0.27 (0.10), 0.17 (0.06), 0.25 (0.10) | 1071, 150, 150, 3429, 207 | G | 0.45 | |
| rs568938 | Chr2: 21080744 | LDL-C, Smoking | ARIC, ARIC, ARIC, MEC, ARIC, MEC. MEC | RE-CALIBRATED LDL CHOL. in mg/dl, LN+1 RE-CALIBRATED LDL CHOL. in mg/dl, LN+1 Smoking duration, Smoking duration (years) reported at baseline, Smoking duration, LDL cholesterol, LN+1 Smoking duration (years) reported at baseline | 7.14e-7, 2.53e-6, 1.11e-3, 7.44e-3, 8.82e-3, 9.11e-3, 9.15e-3 | 5.44 (1.10), 0.04 (8.68e-3), 0.06 (0.02), 0.32 (0.12), 1.04 (0.40), 8.75 (3.34), 0.12 (0.05) | 3162, 3162, 1751, 443, 1753, 380, 443 | A | 0.42 | |
| * | rs6722366 | Chr2: 27809087 | Insulin, Height | WHI, ARIC, ARIC, ARIC, ARIC, MEC, MEC | Insulin, LN+1 STANDING HEIGHT TO NEAREST CM, STANDING HEIGHT TO NEAREST CM, INSULIN (UU-ML), INSULIN in pmol/L, LN+1 Height (cm), Height (cm) | 2.91e-7, 3.71e-4, 4.44e-4, 1.71e-3, 1.71e-3, 4.83e-3, 5.31e-3 | 23.15 (4.50), -1.29e-2 (3.62e-3), -2.16e0 (0.61), 10.25 (3.27), 73.53 (23.42), -3.13e-2 (0.01), -5.43e0 (1.94) | 1718, 3332, 3332, 3243, 244, 451, 451 | C | 0.027 |
| * | rs56197751 | Chr2: 27835291 | Insulin, Height | WHI, ARIC, ARIC, ARIC, ARIC, MEC, MEC | Insulin, LN+1 STANDING HEIGHT TO NEAREST CM, STANDING HEIGHT TO NEAREST CM, INSULIN (UU-ML), INSULIN in pmol/L, LN+1 Height (cm), Height (cm) | 2.60e-7, 6.78e-4, 8.48e-4, 2.35e-3, 2.35e-3, 4.83e-3, 5.31e-3 | 23.72 (4.59), -1.24e-2 (3.65e-3), -2.07e0 (0.62), 9.92 (3.26), 71.15 (23.37). -3.13e-2 (0.01), -5.43e0 (1.94) | 1718, 3266, 3266, 3179, 3179, 451, 451 | A | 0.028 |
| * | rs114117339 | Chr2: 27855059 | Insulin, Height | WHI, ARIC, ARIC, ARIC, ARIC, MEC, MEC | Insulin, LN+1 STANDING HEIGHT TO NEAREST CM, STANDING HEIGHT TO NEAREST CM, INSULIN (UU-ML), INSULIN in pmol/L, LN+1 Height (cm), Height (cm) | 2.60e-7, 7.45e-4, 9.16e-4, 1.28e-3, 1.28e-3, 4.83e-3, 5.31e-3 | 23.72 (4.59), -1.23e-2 (3.64e-3), -2.05e0 (0.62), 10.61 (3.29), 76.15 (23.63), -3.13e-2 (0.01), -5.43e0 (1.94) | 1718, 3332, 3332, 3244, 3244, 451, 451 | A | 0.027 |
| * | rs6760908 | Chr2: 27855874 | Insulin, Height | WHI, ARIC, ARIC, ARIC, ARIC, MEC, MEC | insulin, LN+1 STANDING HEIGHT TO NEAREST CM, INSULIN (UU-ML), INSULIN in pmol/L, STANDING HEIGHT TO NEAREST CM, LN+1 Height (cm), Height (cm) | 2.60e-7, 7.53e-4, 8.32e-4, 8.32e-4, 9.27e-4, 4.83e-3, 5.31e-3 | 23.72 (4.59), -1.23e-2 (3.64e-3), 10.79 (3.23), 77.42 (23.14), -2.05e0 (0.62), -3.13e-2 (0.01), -5.43e0 (1.94) | 1718, 3330, 3242, 3242, 3330, 451, 451 | A | 0.027 |
| rs12622858 | Chr2: 50130369 | Hemoglobin, Hematocrit | WHI, WHI, ARIC, WHI, ARIC, WHI, ARIC | Hemoglobin, LN+1 Hemoglobin, LN+1 HEMOGLOBIN, Hematocrit, HEMOGLOBIN, LN+1 Hematocrit, LN+1 HEMATOCRIT | 3.45e-4, 2.13e-3, 2.63e-3, 4.98e-3, 6.00e-3, 7.24e-3, 7.77e-3 | 0.15 (0.04), 9.01e-3 (2.93e-3), 8.37e-3 (2.78e-3), 0.35 (0.13), 0.12 (0.05), 8.09e-3 (3.01e-3), 7.50e-3 (2.82e-3) | 2086, 2086, 3206, 2087, 3206, 2087, 3206 | A | 0.21 | |
| rs17033788 | Chr2: 67566015 | Hormone Use, Hypertension | ARIC, MEC, ARIC, WHI, WHI, ARIC, WHI | EVER TAKEN FEMALE HORMONES?, Age started estrogen: reported at baseline, Blood Pressure Lowering Medications in the past 2 weeks—Took medication, Hypertension ever (Y/N), Age told of hypertension, Never used hormones, LN+1 Age told of hypertension | 2.60e-3, 3.52e-3, 5.60e-3, 6.36e-3, 6.66e-3, 6.84e-3, 7.03e-3 | -5.16e-1 (0.17), 1.91 (0.60), -3.26e-1 (0.12), -3.51e-1 (0.13), -3.97e-1 (0.15), 0.44 (0.16), -1.43e-1 (0.05) | 2064, 35, 3429, 2059, 2048, 3429, 2048 | C | 0.059 | |
| * | rs13186242 | Chr5: 136857921 | Smoking, Hypertension | ARIC, ARIC, ARIC, ARIC, ARIC, WHI, ARIC, WHI, WHI, WHI, WHI, WHI, WHI, ARIC, WHI, WHI | LN+1 CIGARETTE YEARS OF SMOKING, Blood Pressure Lowering Medications in the past 2 weeks—Took medication, Blood Pressure Lowering Medications in the past 2 weeks—Did not, Cigarette smoking status—Never smoker, HAVE YOU EVER SMOKED CIGARETTES? (Y/N), Age told of hypertension, CIGARETTE YEARS OF SMOKING, Never hypertensive (Y/N), LN+1 Age told of hypertension, Pack years of smoking, LN+1 Pack years of smoking, Smoking—Never (Y/N), Hypertension ever (Y/N), AGE 1ST REGULARLY SMOKED CIGARETS, Smoking—Former (Y/N), Treated hypertensive | 3.94e-4, 5.74e-4, 1.19e-3, 1.33e-3, 1.61e-3, 3.49e-3, 4.18e-3, 4.30e-3, 4.85e-3, 4.96e-3, 5.92e-3, 7.42e-3, 7.85e-3, 8.30e-3, 9.77e-3, 9.94e-3 | 0.29 (0.08), -1.94e-1 (0.06), 0.18 (0.06), -1.84e-1 (0.06), 0.18 (0.06), -2.37e-1 (0.08), 31.35 (10.94), 0.20 (0.07), -8.32e-2 (0.03), 1.38 (0.49), 0.13 (0.05), -1.86e-1 (0.07), -1.88e-1 (0.07), -6.30e-1 (0.24), 0.18 (0.07), -1.82e-1 (0.07) | 3231, 3427, 3427, 3427, 3334, 2047, 3231, 2185, 2047, 2016, 2016, 2185, 2058, 1763, 2185, 2185 | A | 0.28 |
| rs4958487 | Chr5: 151684113 | Glucose, Hypertension | ARIC, ARIC, ARIC, ARIC, WHI, WHI | LN+1 DERIVED GLUCOSE VALUE in mg/dl, HIGH BP EVER DIAGNOSED?, DERIVED GLUCOSE VALUE in mg/dl, HYPERTENSION,DEFINITION 5, Age told of hypertension, LN+1 glucose | 1.29e-3, 6.65e-3, 6.65e-3, 6.71e-3, 7.21e-3, 8.38e-3 | 0.03 (8.14e-3), 0.14 (0.05), 3.92 (1.44), 0.14 (0.05), 0.20 (0.07), 0.02 (7.65e-3) | 3245, 3301, 3245, 3325, 2048, 2000 | A | 0.40 | |
| * | rs9349379 | Chr6: 12903725 | Smoking, Diabetes, Hypertension | MEC, WHI, ARIC, WHI, WHI, WHI, MEC, ARIC, WHI | Ever smoke? (reported at baseline) (Y/N), LN+1 F33 Age started treatment for diabetes, HIGH BP EVER DIAGNOSED?, Age started treatment for diabetes, Smoking—Never (Y/N), Smoking—Former (Y/N), Diabetes reported at baseline (Y/N), Diabetes—lower threshold 126 mg/dL—YES, Treated hypertensive (Y/N) | 1.69e-3, 2.35e-3, 2.50e-3, 2.62e-3, 2.68e-3, 5.61e-3, 5.73e-3, 6.94e-3, 9.01e-3 | 0.84 (0.27), 0.03 (0.01), -2.75e-1 (0.09), 2.13 (0.70), -3.09e-1 (0.10), 0.29 (0.10), -1.20e0 (0.43), -3.24e-1 (0.12), -2.73e-1 (0.10) | 451, 668, 3301, 668, 2186, 2186, 455, 3430, 2186 | G | 0.099 |
| rs79239785 | Chr6: 20602709 | Alcohol, Hypertension | WHI, WHI, WHI, WHI, MEC, ARIC, ARIC | LN+1 Age told of hypertension, Hypertension ever (Y/N), Never hypertensive (Y/N), Age told of hypertension, Ethanol Drinks Per Day—<1, Drinker Status—Current drinker (Y/N), Blood Pressure Lowering Medications in the past 2 weeks—Took medication | 3.84e-3, 4.55e-3, 5.22e-3, 6.26e-3, 7.26e-3, 9.28e-3, 9.72e-3 | 0.26 (0.09), 0.67 (0.24), -6.70e-1 (0.24), 0.69 (0.25), 1.39 (0.52), 0.47 (0.18), 0.44 (0.17) | 2048, 2059, 2186, 2048, 549, 3430, 3430 | A | 0.020 | |
| rs1728312 | Chr7: 23231308 | Smoking, Alcohol | WHI, WHI, WHI, MEC, ARIC, WHI | Age quit smoking, LN+1 Age quit smoking, LN+1 alcohol intake, Ethanol Drinks Per Day—<1, LN+1 AGE 1ST REGULARLY SMOKED CIGARETTES, alcohol intake | 3.12e-3, 4.74e-3, 5.73e-3, 6.41e-3, 7.83e-3, 8.38e-3 | 0.86 (0.29), 0.11 (0.04), -7.38e-2 (0.03), 0.86 (0.31), -6.12e-2 (0.02), -2.70e-1 (0.10) | 760, 760, 2060, 549, 1763, 2060 | G | 0.050 | |
| rs2390859 | Chr7: 23995928 | Smoking, Heart arterial surgery | MEC, MEC, ARIC, MEC, MEC, ARIC, WHI, ARIC, MEC | Ever smoke? (reported at baseline) (Y/N), LN+1 Smoking duration (years) reported at baseline, AGE STOPPED SMOKING CIGARETTES, Smoking duration (years) reported at baseline, LN+1 Pack-years of smoking (cigarettes) reported at baseline, LN+1 AGE STOPPED SMOKING CIGARETTES, LN+1 Coronary bypass surgery ever (Y/N), Coronary Bypass surgery? Yes, Pack-years of smoking (cigarettes) reported at baseline | 3.69e-3, 4.01e-3, 4.14e-3, 5.76e-3, 6.24e-3, 8.19e-3, 8.30e-3, 8.38e-3, 9.00e-3 | 0.66 (0.23), 0.18 (0.06), 2.09 (0.73), 0.44 (0.16), 0.12 (0.04), 0.05 (0.02), 0.96 (0.36), 0.87 (0.33), 0.42 (0.16) | 451, 443, 771, 443, 435, 771, 2089, 3429, 435 | A | 0.17 | |
| rs4722315 | Chr7: 24006654 | Smoking, Heart arterial surgery | MEC, MEC, MEC, MEC, WHI, ARIC, MEC, ARIC | LN+1 Smoking duration (years) reported at baseline, Smoking duration (years) reported at baseline, Ever smoke? (reported at baseline) (Y/N), LN+1 Pack-years of smoking (cigarettes) reported at baseline, Coronary bypass surgery ever (Y/N), Coronary Bypass surgery? Yes, Pack-years of smoking (cigarettes) reported at baseline, AGE STOPPED SMOKING CIGARETTES | 4.84e-3, 5.61e-3, 6.82e-3, 7.05e-3, 7.54e-3, 7.71e-3, 8.77e-3, 8.95e-3 | 0.18 (0.06), 0.44 (0.16), 0.61 (0.23), 0.12 (0.04), 0.98 (0.37), 0.88 (0.33), 0.43 (0.16), 1.91 (0.73) | 443, 443, 451, 435, 2089, 3429, 435, 771 | G | 0.17 | |
| rs2106922 | Chr7: 27969614 | Hemoglobin, Hematocrit | WHI, WHI, WHI, ARIC, WHI, ARIC | LN+1 Hemoglobin, Hemoglobin, LN+1 Hematocrit, Hematocrit, Hematocrit, Hematocrit | 4.70e-5, 2.84e-4, 1.55e-3, 2.08e-3, 3.74e-3, 8.17e-3 | -0.012(2.84e-3), -0.15(0.04), -9.25e-3(2.92e-3), -0.14(0.05), -0.354(0.12), -0.36(0.13) | 2086, 2086, 2087, 3212, 2087, 3212 | A | 0.22 | |
| rs114374279 | Chr7: 44532122 | Alcohol, Smoking | ARIC, WHI, WHI, MEC, MEC | Drinker Status—Current drinker, LN+1 years a regular smoker, years a regular smoker, Ethanol Drinks Per Day—<2, LN+1 Number of years since quit smoking (reported at baseline) | 1.38e-3, 5.02e-3, 5.54e-3, 9.28e-3, 9.67e-3 | 0.52 (0.16), -2.53e-1 (0.09), -6.77e-1 (0.24), 1.49 (0.57), -3.48e-1 (0.13) | 3424, 2029, 2029, 549, 230 | G | 0.020 | |
| rs11983880 | Chr7: 73708374 | Glucose, Diabetes | WHI, ARIC, WHI, WHI, ARIC, ARIC, WHI | LN+1 glucose, LN+1 DERIVED GLUCOSE VALUE in mg/dl, glucose, Diabetes ever, Diabetes—lower threshold 126 mg/dL—YES, DERIVED GLUCOSE VALUE in mg/dl, treated diabetes | 1.05e-3, 1.47e-3, 1.48e-3, 3.02e-3, 3.07e-3, 4.39e-3, 7.35e-3 | 0.04 (0.01), 0.04 (0.01), 5.50 (1.73), 0.45 (0.15), 0.29 (0.10), 6.80 (2.39), 0.29 (0.11) | 2000, 3186, 2000, 2086, 3370, 3186, 2089 | A | 0.10 | |
| rs10974448 | Chr9: 4308010 | Hematocrit, Hemoglobin | WHI, ARIC, WHI, WHI, WHI, ARIC, ARIC | Hemoglobin, LN+1 HEMOGLOBIN, LN+1 Hemoglobin, LN+1 Hematocrit, Hematocrit, LN+1 HEMATOCRIT, HEMOGLOBIN | 2.04e-3, 2.12e-3, 2.18e-3, 4.14e-3, 5.98e-3, 7.13e-3, 8.65e-3 | 0.14 (0.04), 8.95e-3 (2.91e-3), 9.20e-3 (3.00e-3), 8.83e-3 (3.08e-3), 0.35 (0.13), 7.93e-3 (2.95e-3), 0.12 (0.05) | 2086, 3212, 2086, 2087, 2087, 3212, 3212 | A | 0.20 | |
| rs2756916 | Chr9: 101915669 | BMI, CRP | ME, MEC, WHI, MEC, WHI, WHI, MEC | Body mass index (BMI) calculated from weight & height at baseline, LN+1 BMI Body mass index (BMI) calculated from weight & height at baseline, CRP, LN+1 C-Reactive Protein, LN+1 Body mass index (BMI) calculated from weight & height at baseline, Body mass index (BMI) calculated from weight & height at baseline, C-Reactive Protein | 1.28e-3, 1.98e-3, 2.94e-3, 4.21e-3, 5.07e-3, 6.40e-3, 8.65e-3 | 3.28 (1.01), 0.11 (0.03), 5.20 (1.75), 0.49 (0.17), 0.05 (0.02), 1.61 (0.59), 2.17 (0.82) | 445, 445, 107, 380, 2062, 2062, 380 | C | 0.026 | |
| rs7923036 | Chr10: 1433616, | MI, Smoking | ARIC, ARIC, WHI, MEC, MEC, ARIC | LN+1 age at first heart attack, Age at first heart attack, MI, LN+1 Number of years since quit smoking (reported at baseline), Number of years since quit smoking (reported at baseline), Number of years abstained from cigarettes | 2.04e-4, 7.47e-4, 1.06e-3, 1.57e-3, 3.50e-3, 6.89e-3 | -0.12 (0.03), -4.78 (1.38), 0.59 (0.18), 0.15 (0.05), 0.64 (0.22), 0.92 (0.34) | 109, 109, 2089, 230, 230, 511 | G | 0.19 | |
| rs787037 | Chr10: 26504353 | Smoking, HDL-C | WHI, WHI, ARIC, ARIC | Smoking—Never, normalized HDL, Smoking duration, RE-CALIBRATED HDL CHOL. in mg/dl | 9.75e-4, 7.78e-3, 8.57e-3, 9.02e-3 | -2.43e-1 (0.07), -3.06e-2 (0.01), 0.06 (0.02), -2.44e-2 (9.35e-3) | 2186, 1383, 1745, 3181 | G | 0.21 | |
| rs17875327 | Chr10: 92515052 | Insulin, Triglycerides | WHI, WHI, WHI, ARIC, ARIC, ARIC, ARIC, ARIC | insulin, normalized natural log transformed triglycerides, LN+1 normalized natural log transformed triglycerides, LN+1 INSULIN (UU-ML), TOTAL TRIGLYCERIDES in mmol/L, triglycerides mg/dL, LN+1 INSULIN in pmol/L, LN+1 TOTAL TRIGLYCERIDES in mmol/L | 3.63e-5, 1.25e-3, 1.72e-3, 5.62e-3, 5.68e-3, 5.68e-3, 7.05e-3, 7.39e-3 | 21.55 (5.20), 0.17 (0.05), 0.03 (9.35e-3), 0.21 (0.07), 0.24 (0.09), 20.86 (7.54), 0.21 (0.08), 0.07 (0.03) | 1718, 1190, 1190, 3244, 3189, 3189, 3244, 3189 | G | 0.018 | |
| rs942008 | Chr10: 96397655 | Hypertension, SBP | ARIC, WHI, WHI, WHI, ARIC, WHI, ARIC, WHI, WHI, ARIC, ARIC, WHI | HIGH BP EVER DIAGNOSED?, Never hypertensive (Y/N), Treated hypertensive (Y/N), Hypertension ever (Y/N), Blood Pressure Lowering Medications in the past 2 weeks—Took medication, Age told of hypertension, Blood Pressure Lowering Medications in the past 2 weeks—Did not take, LN+1 systolic blood pressure, systolic blood pressure, 2ND AND 3RD SYSTOLIC BP AVERAGE, LN+1 2ND AND 3RD SYSTOLIC BP AVERAGE, Age told of hypertension | 2.39e-4, 4.58e-4, 8.00e-4, 1.13e-3, 1.66e-3, 2.61e-3, 3.06e-3, 3.25e-3, 4.01e-3, 4.40e-3, 5.55e-3, 6.22e-3 | 0.24 (0.07), -2.90e-1 (0.08), 0.27 (0.08), 0.27 (0.08), 0.20 (0.06), 0.10 (0.03), -1.89e-1 (0.06), 0.02 (5.33e-3), 2.04 (0.71), 1.89 (0.66), 0.01 (4.85e-3), 0.26 (0.09) | 3301, 2186, 2186, 2059, 3430, 2048, 3430, 2089, 2089, 3337, 3337, 2048 | G | 0.18 | |
| rs76394293 | Chr11: 17372388 | Insulin, Glucose | WHI, WHI, ARIC, ARIC, ARIC, WHI | insulin, glucose, INSULIN (UU-ML), DERIVED GLUCOSE VALUE in mg/dl, INSULIN in pmol/L, glucose | 1.07e-3, 3.63e-3, 5.05e-3, 5.48e-3, 5.63e-3, 8.39e-3 | 13.74 (4.19), 8.78 (3.01), 0.15 (0.05), 10.75 (3.87), 0.15 (0.06), 0.06 (0.02) | 1718, 2000, 3244, 3245, 3244, 2000 | A | 0.032 | |
| rs1939120 | Chr11:64537243 | Smoking, Hematocrit | WHI, ARIC, WHI, MEC, WHI | Smoking—Former, LN+1 HEMATOCRIT, Hematocrit, Currently smoke? (reported at baseline) (Y/N), LN+1 Hematocrit | 2.72e-3, 4.96e-3, 8.14e-3, 8.85e-3, 9.24e-3 | 0.20 (0.07), 6.70e-3 (2.38e-3), 0.28 (0.11), 0.48 (0.18), 6.57e-3 (2.52e-3) | 2186, 3210, 2087, 450, 2087 | A | 0.37 | |
| rs17376366 | Chr12: 20339790 | Stroke, Creatinine | WHI, WHI, MEC, ARIC, ARIC | Age stroke, LN+1 Age stroke, Urinary Creatinine, New Maternal History of Stroke (Y/N), CREATININE (MG-DL) | 2.38e-3, 3.10e-3, 7.60e-3, 9.20e-3, 9.31e-3 | 6.94 (2.20), 0.10 (0.03), 24.66 (9.17), 0.33 (0.13), 0.10 (0.04) | 76, 76, 274, 3042, 3244 | G | 0.076 | |
| rs115487129 | Chr12: 89395852 | Smoking, Alcohol | WHI, MEC, ARIC, WHI, ARIC | Smoking—current (Y/N), Ethanol Drinks Per Day—2+ drinks, Smoking duration, alcohol intake, LN+1 Smoking duration | 1.44e-3, 3.60e-3, 4.97e-3, 8.34e-3, 9.14e-3 | 0.61 (0.19), 1.15 (0.39), -2.44e0 (0.87), 0.27 (0.10), -1.12e-1 (0.04) | 2186, 549, 1753, 2061, 1751 | C | 0.052 | |
| * | rs7139221 | Chr12: 110853890 | Insulin, Smoking | WHI, ARIC, ARIC, ARIC, WHI | insulin, LN+1 AGE STOPPED SMOKING CIGARETTES, AGE STOPPED SMOKING CIGARETTES, LN+1 INSULIN (UU-ML), Pack years of smoking | 1.47e-3, 3.12e-3, 4.14e-3, 6.04e-3, 9.28e-3 | 6.97 (2.19), -6.23e-2 (0.02), -2.37e0 (0.82), 0.07 (0.03), -1.70e0 (0.65) | 1718, 771, 771, 3243, 2017 | A | 0.14 |
| * | rs61944267 | Chr12: 110856526 | Insulin, Smoking | WHI, ARIC, ARIC, ARIC, WHI, ARIC | insulin, LN+1 AGE STOPPED SMOKING CIGARETTES, AGE STOPPED SMOKING CIGARETTES, LN+1 INSULIN (UU-ML), Pack years of smoking, LN+1 INSULIN in pmol/L | 1.66e-3, 3.70e-3, 4.94e-3, 5.67e-3, 6.78e-3, 9.24e-3 | 6.82 (2.16), -6.13e-2 (0.02), -2.33e0 (0.83), 0.07 (0.03), -1.75e0 (0.65), 0.07 (0.03) | 1718, 770, 770, 3242, 2017, 3242 | G | 0.14 |
| * | rs113945414 | Chr12: 110859018 | Insulin, Smoking | WHI, ARIC, ARIC, ARIC, WHI, ARIC | Insulin, LN+1 AGE STOPPED SMOKING CIGARETTES, LN+1 INSULIN (UU-ML), AGE STOPPED SMOKING CIGARETTES, pack years of smoking, LN+1 INSULIN in pmol/L | 1.45e-3, 3.46e-3, 4.42e-3, 4.54e-3, 6.80e-3, 7.31e-3 | 6.90 (2.16), -6.16e-2 (0.02), 0.08 (0.03), -2.34e0 (0.82), -1.75e0 (0.65), 0.08 (0.03) | 1718, 771, 3243, 771, 2017, 3243 | A | 0.15 |
| rs10774711 | Chr:113697994 | SBP, MI | ARIC, WHI, WHI, ARIC, WHI, ARIC, WHI | 2ND AND 3RD SYSTOLIC BP AVERAGE, LN+1 Age at MI, Age at MI, HEART ATTACK EVER DIAGNOSED?, LN+1 systolic blood pressure, LN+1 2ND AND 3RD SYSTOLIC BP AVERAGE, systolic blood pressure | 3.37e-3, 3.61e-3, 4.10e-3, 4.25e-3, 5.86e-3, 6.78e-3, 7.41e-3 | -1.53e0 (0.52), -4.92e-2 (0.02), -3.40e0 (1.15), -3.47e-1 (0.12), -1.11e-2 (4.03e-3), -1.04e-2 (3.83e-3), -1.44e0 (0.54) | 3334, 77, 77, 3305, 2089, 3334, 2089 | A | 0.49 | |
| rs60136502 | Chr15: 90965307 | Insulin, Total Cholesterol | WHI, MEC, ARIC, ARIC, ARIC, ARIC, WHI | insulin, LN+1 Insulin, TOTAL CHOLESTEROL in mmol/L, total cholesterol mg/dL, LN+1 TOTAL CHOLESTEROL in mmol/L, LN+1 total cholesterol mg/dL, total cholesterol | 1.32e-3, 1.52e-3, 5.85e-3, 5.85e-3, 7.26e-3, 7.38e-3, 8.18e-3 | 7.38 (2.29), 0.22 (0.07), 0.13 (0.05), 4.99 (1.81), 0.02 (7.11e-3), 0.02 (8.44e-3), 6.48 (2.45) | 1718, 442, 3182, 3182, 3182, 3182, 1417 | C | 0.11 | |
| rs11865790 | Chr16: 47399623 | Alcohol, CRP | ARIC, WHI, ARIC, MEC, WHI | Drinker Status—Current drinker, LN+1 alcohol intake, LN+1 C-reactive Protein, LN+1 C-Reactive Protein, alcohol intake | 2.65e-4, 5.57e-3, 7.59e-3, 7.78e-3, 9.31e-3 | 0.21 (0.06), -3.45e-2 (0.01), 0.31 (0.12), 0.15 (0.06), -1.24e-1 (0.05) | 3428, 2061, 151, 380, 2061 | G | 0.35 | |
| rs8058543 | Chr16: 53096347 | Heart Arterial Surgery, MI | WHI, ARIC, ARIC, ARIC, ARIC, ARIC, WHI | Percutaneous transluminal coronary angioplasty (Y/N), Heart or arterial surgery? No, MI by 2007 (Y/N), Heart or arterial surgery? Yes, Coronary Bypass surgery? No, LEFT HEART OR ART SURG—left leg, MI ever (Y/N) | 3.00e-4, 5.32e-4, 9.00e-4, 1.21e-3, 3.90e-3, 5.43e-3, 6.32e-3 | 1.76 (0.49), -1.02e0 (0.30), 0.60 (0.18), 1.05 (0.32), 1.11 (0.38), 2.47 (0.89), 1.12 (0.41) | 2044, 3429, 3339, 3429, 3429, 3429, 2088 | A | 0.044 | |
| * | rs2926143 | Chr16: 64224173 | Hypertension, Smoking | MEC, ARIC, WHI, WHI, ARIC, WHI, WHI | High blood pressure reported at baseline, HYPERTENSION DEFINITION 5, Never hypertensive (Y/N), Hypertension ever (Y/N), CIGARETTE YEARS OF SMOKING, LN+1 Age told of hypertension, Pack years of smoking | 1.03e-3, 1.24e-3, 4.41e-3, 4.58e-3, 7.11e-3, 7.65e-3, 9.58e-3 | -4.47e-1 (0.14), -1.59e-1 (0.05), -1.78e-1 (0.06), 0.18 (0.06), 26.25 (9.75), 0.07 (0.03), 1.13 (0.44) | 455, 3325, 2186, 2059, 3234, 2048, 2017 | G | 0.49 |
| rs4260044 | Chr16: 85238638 | BMI, CRP | ARIC, ARIC, MEC, MEC, ARIC, MEC, MEC | BODY MASS INDEX IN KG/(M*M), LN+1 BODY MASS INDEX IN KG/(M*M), Body mass index (BMI) calculated from weight & height at baseline, LN+1 BMI Body mass index (BMI) calculated from weight & height at baseline, Log (CRP), LN+1 C-Reactive Protein, C-Reactive Protein | 4.39e-4, 8.07e-4, 1.10e-3, 1.82e-3, 2.72e-3, 5.26e-3, 7.52e-3 | 0.54 (0.15), 0.02 (4.80e-3), 1.01 (0.31), 0.03 (0.01), 0.24 (0.08), 0.14 (0.05), 0.65 (0.24) | 3327, 3327, 445, 445, 378, 380, 380 | A | 0.48 | |
| * | rs4334353 | Chr17: 55374378 | Smoking, MI | ARIC, ARIC, ARIC, MEC, ARIC, WHI, MEC | AGE 1ST REGULARLY SMOKED CIGARETS Q29, AGE 1ST REGULARLY SMOKED CIGARETS Q29, AGE AT FIRST HEART ATTACK, Number of years since quit smoking (reported at baseline), AGE AT FIRST HEART ATTACK, age at MI, Number of years since quit smoking (reported at baseline) | 1.02e-4, 1.30e-3, 2.62e-3, 6.51e-3, 6.83e-3, 8.33e-3, 9.88e-3 | 0.04 (0.01), 0.77 (0.24), -9.08e-2 (0.03), 0.50 (0.18), -3.42e0 (1.24), -2.39e-1 (0.08), 0.10 (0.04) | 1723, 1723, 109, 230, 109, 27, 230 | A | 0.32 |
Abbreviations: allele frequency (AF), C-reactive protein (CRP), coded allele (CA), direction of effect (DE), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), systolic blood pressure (SBP), myocardial infarction (MI), standard error (SE)