Fig 7. The AMPK activator AICAR attenuates palmitate-induced markers of cellular adhesion and ER stress.

Cells were pretreated with AICAR (0.5mM) for 2hr then co-incubated with palmitate (PA). Fold change from control in a) ICAM-1, b) ATF4, c) ATF5, d) GADD34, e) GRP78 and f) CHOP expression after treatment with palmitate (PA) 0.25 and 0.5mM, or co-treatment with the AMPK activator AICAR (0.5mM). Data are expressed as mean±SEM, n = 3 independent experiments, *p<0.05 vs control.