Fig 9. The AMPK inhibitor CC prevents protective effects of AICAR against palmitate.

Cells were pretreated with AICAR (0.1 or 0.5mM) alone or in combination with compound C (CC; 20 or 40μM) and then co-incubated with palmitate (PA). Fold change from control in a) viability and b) apoptosis after treatment with palmitate (PA), compound C (CC), and AICAR. Data are expressed as mean±SEM; n = 3–6 independent experiments; *p<0.05 vs control, #p<0.05 vs PA+AICAR at equimolar doses.