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. 2019 Dec 31;14(12):e0226733. doi: 10.1371/journal.pone.0226733

Fig 7. UNC1999 treatment three days in vivo is sufficient cause functional changes in EZH2 target gene expression and H3K27me3 levels.

Fig 7

(A) Schematic demonstrating how tissue was harvested to assess EZH2 target gene expression levels post UNC1999 treatment. B) Expression levels of EZH2 target genes are de-repressed after treatment with UNC1999 (multiple t-tests, p <0.05, with Holm-Sidak correction). (C) EZH2 protein levels do not change eight days after UNC1999 treatment. (D) Increased H3K27me3 levels detected at 10 days in KA + vehicle treated animals are reduced with treatment of UNC1999. Statistical significance assessed by Student’s unpaired t-test with equal SD (p < 0.05), n = 6 saline + vehicle, n = 3 KA + vehicle and n = 7 KA + UNC1999 animals. *p <0.05, **p < 0.01, ***p< 0.001, ****p <0.0001.