Table 1.
Univariate Cox regression results
| Metric | PFS—HR (95% CI) | PFS—p-value | OS—HR (95% CI) | OS—p-value |
|---|---|---|---|---|
| Skewness | 2.5 (1–6) | 0.044* | 2.5 (1–6.1) | 0.04* |
| Kurtosis | 2 (0.94–4.3) | 0.073* | 2.4 (1.1–5.5) | 0.035* |
| Entropy | 0.7 (0.31–1.6) | 0.39 | 0.97 (0.41–2.3) | 0.94 |
| Median | 3.3 (1.6–6.7) | 0.001* | 1.9 (0.91-4) | 0.088* |
| Mode | 0.91 (0.42-2) | 0.81 | 0.94 (0.41–2.1) | 0.88 |
| p15 | 2.6 (1.1-6) | 0.029* | 3.2 (1.4–7.5) | 0.008* |
| p85 | 0.3 (0.13–0.67) | 0.004* | 0.29 (0.13–0.64) | 0.002* |
| MGMT | 0.42 (0.19–0.91) | 0.027* | 0.3 (0.12–0.7) | 0.006* |
| Treatment | 1.1 (0.55–2.2) | 0.78 | 0.79 (0.37–1.7) | 0.53 |
PFS progression-free survival, OS overall survival, MGMT MGMT methylation status
*Indicate that the covariate was below threshold (p < 0.1) and included in further analyses