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. 2019 Dec 31;9:20399. doi: 10.1038/s41598-019-56551-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Passive transfer of CHIKV immune sera does not provide cross-protection against MAYV infection and disease in an immunocompromised mouse model. (a) Virus-specific neutralizing antibody titers (solid bars) and MAYV cross-neutralizing antibody titers (empty bars) were determined prior to MAYV challenge. Dashed line indicates the upper and lower limits of detection (1:640 and 1:20, respectively). (b) Weight change, expressed as percent of original, and (c) footpad swelling were determined daily throughout the study. (d) Viremia was measured daily for four days post-infection and (e) survival was recorded. All plotted values in (b–d) are mean ± S.D. Data in (b-d) were analyzed using a one-way ANOVA with a Bonferroni post hoc analysis, and survival curves (e) were analyzed by Kaplan-Meier survival analysis. When compared to the PBS control (i.e. PBS-vaccinated and PBS-challenged), statistically significant footpad swelling was observed in mice from EILV/CHIKV on days 2–6, CHIKV/IRES on days 1 and 3–6, and ZIKV, CHIKV-99659 and sham on days 3–6. Weight change was statistically significant for EILV/CHIKV on days three and five, and CHIKV-99659 on days three and four, and sham on day four. Viremia (days 1–4) and survival was statistically significant for all groups except MAYV/IRES. Statistically significant values are denoted by * p<0.05.