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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: J Physiol. 2019 Dec 9;598(1):171–187. doi: 10.1113/JP278747

Figure 4.

Figure 4.

A single 50ms pulse of light significantly reduces seizure duration in VGluT-ChR animals. A) Data from an example opsin-positive animal; blue bars: events receiving blue (473nm) light intervention; hashed bars: no-light internal controls; top trace illustrates pulsed light delivery paradigm (50% reduction, p < 0.001, two sample Kolmogorov-Smirnov test). Inset: first 5s bin expanded, 1s bin size. B) No effect of blue (473nm) light delivery in an opsin negative animal (p = 0.237, two sample Kolmogorov-Smirnov test). Single pulses of light in opsin positive VGluT2-ChR animals significantly reduce seizure duration when targeting either contralateral (C) or ipsilateral (D) fastigial nucleus (each gray data point represents one animal, black data points represent mean).