Table 2:
Population analysis on apnea-hypopnea index (AHI) statistical uncertainty using data from the MESA study. For the 278 subjects symptomatic (ESS>10) population and the 2049 subjects in the full population, the table summarizes the number of subjects in the following classes: Currently Eligible – subjects qualifying for treatment under current standards (AHI>Threshold), Uncertain Diagnoses – subjects for whom the threshold is contained within the upper and lower 95% confidence bounds on the AHI (Lower Bound < Threshold < Upper Bound)—separated into percent uncertain subjects above and below threshold, Uncertain Subjects Eligible – subjects qualifying if all uncertain subjects are eligible (Upper Bound > Threshold), Uncertain Subjects Ineligible – subjects qualifying if all uncertain subjects are excluded (Lower Bound > Threshold). Population proportion percentages are reported with the exact binomial 95% confidence interval in curly braces.
| Symptomatic (ESS>10) Population: Threshold - AHI ≥ 5 | ||||
|---|---|---|---|---|
| 3% Desaturation | Empirical | Poisson | ||
| Currently Eligible | 225/278 | 80.94% {75.82% 85.38%} | 225/278 | 80.94% {75.82% 85.38%} |
| Uncertain Diagnoses | 76/278 | 27.34% {22.19% 32.98%} | 52/278 | 18.71% {14.30% 23.79%} |
| Below Threshold | 48/76 | 63.16% {51.31% 73.94%} | 28/52 | 53.85% {39.47% 67.77%} |
| Above Threshold | 28/76 | 36.84% {26.06% 48.69%} | 24/52 | 46.15% {32.23% 60.53%} |
| Uncertain Subjects Eligible | 273/278 | 98.20% {95.85% 99.41%} | 253/278 | 91.01% {87.01% 94.10%} |
| Uncertain Subjects Ineligible | 197/278 | 70.86% {65.14% 76.14%} | 201/278 | 72.30% {66.64% 77.48%} |
| Full Population: Threshold - AHI ≥ 15 | ||||
| 3% Desaturation | Empirical | Poisson | ||
| Currently Eligible | 736/2049 | 35.92% {33.84% 38.04%} | 736/2049 | 35.92% {33.84% 38.04%} |
| Uncertain Diagnoses | 880/2049 | 42.95% {40.79% 45.12%} | 435/2049 | 21.23% {19.48% 23.07%} |
| Below Threshold | 624/880 | 70.91% {67.78% 73.89%} | 254/435 | 58.39% {53.60% 63.07%} |
| Above Threshold | 256/880 | 29.09% {26.11% 32.22%} | 181/435 | 41.61% {36.93% 46.40%} |
| Uncertain Subjects Eligible | 1360/2049 | 66.37% {64.28% 68.42%} | 990/2049 | 48.32% {46.13% 50.51%} |
| Uncertain Subjects Ineligible | 480/2049 | 23.43% {21.61% 25.32%} | 555/2049 | 27.09% {25.17% 29.07%} |