Table 1.
Islet-specific genes are bound by GLIS3
| Hormones | |||
|---|---|---|---|
| Gene | Fold Change | FDR | Glis3 ChIP-seq Signal |
| Ins1 | −2.116517315 | 0.00506878 | yes |
| Ins2 | −2.839350013 | 3.35E-13 | yes |
| Ppy | −8.154862239 | 1.87E-19 | yes |
| Gcg | −1.234894439 | NS | no |
| Sst | 1.083293292 | NS | no |
| Ghrl | 1.095231496 | NS | no |
| Beta cell Function | |||
| Slc2a2 | −5.112554821 | 9.58E-33 | yes |
| Kcnj11 | −1.299797953 | 0.01104388 | yes |
| Abcc8 | 1.444296553 | 0.00016462 | yes |
| Glp1r | −1.848329213 | 0.02182045 | yes |
| Chga | −2.13350168 | 3.53E-22 | yes |
| Ucn3 | −1.588987707 | NS | yes |
| Gjd2 | −1.120393715 | NS | yes |
| Transcription Factors | |||
| MafA | −2.693922579 | 0.00026979 | yes |
| Nkx6.1 | −2.239512577 | 1.03E-09 | yes |
| Rfx6 | 1.349799675 | 0.00446909 | yes |
| Isl1 | 1.640589346 | 4.17E-10 | yes |
| Ldb1 | −1.279981837 | 0.00500245 | yes |
| MafB | −1.496356376 | 0.00324023 | yes |
| FoxA2 | −1.281876971 | 0.045365 | yes |
| Pdx1 | −1.061699976 | NS | yes |
| Tshz1 | 1.084110443 | NS | yes |
| Mnx1 | 1.114782737 | NS | yes |
| InsM1 | 1.102778676 | NS | yes |
| Ngn3 | −1.731654424 | NS | yes |
| Nkx2.2 | −1.211137492 | NS | yes |