Skip to main content
. Author manuscript; available in PMC: 2020 Oct 1.
Published in final edited form as: Endocr Relat Cancer. 2019 Oct;26(10):765–778. doi: 10.1530/ERC-19-0262

Figure 5.

Figure 5.

Apoptosis induced by HITOPK032 is in part mediated by JNK activation. A. HITOPK032 at 1uM or higher induces apoptosis in a dose dependent manner by 48 hours in all cell lines. B. HITOPK treatment induces JNK phosphorylation in CU-ACC1and H295R cell lines. C. Treating CU-ACC1 and H295R cell lines with 10uM of the JNK inhibitor in presence of 4uM HITOPK032 partially inhibits caspase 3/7 activity measured by the caspase 3/7 glo assay. P values (**p<0.01, * p<0.05)) have been calculated from normalized RLU of at least three biological repeats. Quantification of immunoblots have been derived from normalized densitometric values from three independent replicates. All normalization has been done to the DMSO control. Data represented as mean +/−SEM.