Table 3.
Odds of hypertensive organ damage according to hypertension onset age.
| LVH | Coronary calcification | Albuminuria | Diastolic dysfunction | |||||
|---|---|---|---|---|---|---|---|---|
|
| ||||||||
| Hypertension onset age |
n/N | OR (95% CI) | n/N | OR (95% CI) | n/N | OR (95% CI) | n/N | OR (95% CI) |
| Unadjusted model | ||||||||
| <35 | 33/94 | 3.35 (2.16-5.20)* | 22/94 | 4.33 (2.61-7.18)* | 14/94 | 3.49 (1.91-6.36)* | 15/94 | 2.17 (1.22-3.85)† |
| 35-44 | 73/251 | 2.54 (1.88-3.42)* | 40/251 | 2.69 (1.84 −3.92)* | 36/251 | 3.34 (2.23-5.00)* | 31/251 | 1.61 (1.07-2.42)‡ |
| ≥45 | 32/136 | 1.90 (1.26-2.88)† | 28/136 | 3.67 (2.35-5.75)* | 10/136 | 1.58 (0.81-3.10) | 16/136 | 1.52 (0.88-2.62) |
| No hypertension | 306/2199 | 1.00 | 145/2199 | 1.00 | 105/2199 | 1.00 | 177/2199 | 1.00 |
| Multivariable-adjusted model | ||||||||
| <35 | 33/94 | 2.82 (1.67-4.74)* | 22/94 | 3.15 (1.69-5.86)* | 14/94 | 1.49 (0.73-3.02) | 15/94 | 2.04 (1.04-3.99)‡ |
| 35-44 | 73/251 | 2.07 (1.40-3.08)* | 40/251 | 1.94 (1.17-3.23)‡ | 36/251 | 1.63 (0.96-2.76) | 31/251 | 1.58 (0.93-2.69) |
| ≥45 | 32/136 | 1.52 (0.92-2.51) | 28/136 | 1.49 (0.83-2.65) | 10/136 | 0.84 (0.39-1.81) | 16/136 | 1.43 (0.74-2.76) |
| No hypertension | 306/2199 | 1.00 | 145/2199 | 1.00 | 105/2199 | 1.00 | 177/2199 | 1.00 |
| Multivariable+SBP-adjusted model | ||||||||
| <35 | 33/94 | 2.29 (1.36-3.86)† | 22/94 | 2.94 (1.57-5.49)* | 14/94 | 1.12 (0.55-2.29) | 15/94 | 2.06 (1.04-4.05)‡ |
| 35-44 | 73/251 | 1.67 (1.12-2.48)‡ | 40/251 | 1.83 (1.10-3.05)‡ | 36/251 | 1.25 (0.74-2.09) | 31/251 | 1.59 (0.93-2.73) |
| ≥45 | 32/136 | 1.23 (0.74-2.03) | 28/136 | 1.41 (0.79-2.52) | 10/136 | 0.62 (0.29-1.34) | 16/136 | 1.44 (0.75-2.79) |
| No hypertension | 306/2199 | 1.00 | 145/2199 | 1.00 | 105/2199 | 1.00 | 177/2199 | 1.00 |
n/N indicates number of individuals with organ damage/number of individuals in category. LVH, Left ventricular hypertrophy; OR, odds ratio; CI, confidence interval; SBP, systolic blood pressure.
P<0.001;
P<0.01;
P<0.05. Multivariable-adjusted model is adjusted for age, sex, body mass index, total serum cholesterol, HDL-cholesterol, smoking status, use of antihypertensive medication, race and diabetes. Trend test p-values for odds ratios across age groups for LVH, coronary calcification, albuminuria, and diastolic dysfunction were <0.0001, <0.0001, <0.0001, and 0.005, respectively. The corresponding p-values were 0.009, 0.068, 0.56, and 0.16 for the multivariable-adjusted models and 0.12, 0.11, 0.68, and 0.16 for the multivariable+SBP-adjusted models, respectively.