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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Biochim Biophys Acta Gene Regul Mech. 2019 Jul 1;1863(4):194396. doi: 10.1016/j.bbagrm.2019.06.007

Figure 1:

Figure 1:

Epigenetic regulation of MEG3 expression. Overnutrition and obesity increase MEG3 expression by hypomethylating the MEG3 IG-DMR and MEG3 DMR whereas starvation and other stressors contribute to the decrease in MEG3 expression via hypermethylation. MEG3 IGDMR methylation in most tissues decreases with age, with the notable exception of skeletal muscle [32–35]. Consumption of a Mediterranean diet has been associated with lower MEG3 expression.