Figure 2.

Overall adjusted mean change from baseline in EORTC QLQ-C30 scores over the first 6 months of treatment (A) Global Health Status and physical functioning and (B) symptom scales. An adjusted mean change from baseline or between-group difference of ≥10 points was considered to be clinically meaningful. For each subscale, only visits with at least 25% non-missing values in each treatment arm were included, therefore analyses cover only the first 6 months of treatment. Error bars denote 95% confidence intervals. *Between-group differences were considered statistically significant if P<0.05. ^†For diarrhoea, N=53. CI, confidence interval; QoL, quality of life.